Search
Results
-
Distinct Trajectories of Massive Recent Gene Gains and Losses in Populations of a Microbial Eukaryotic Pathogen
(2017)Molecular Biology and EvolutionDifferences in gene content are a significant source of variability within species and have an impact on phenotypic traits. However, little is known about the mechanisms responsible for the most recent gene gains and losses. We screened the genomes of 123 worldwide isolates of the major pathogen of wheat Zymoseptoria tritici for robust evidence of gene copy number variation. Based on orthology relationships in three closely related fungi, ...Journal Article -
Bayesian inference of species networks from multilocus sequence data
(2018)Molecular Biology and EvolutionJournal Article -
The Structured Coalescent and Its Approximations
(2017)Molecular Biology and EvolutionPhylogeographic methods can help reveal the movement of genes between populations of organisms. This has been widely done to quantify pathogen movement between different host populations, the migration history of humans, and the geographic spread of languages or gene flow between species using the location or state of samples alongside sequence data. Phylogenies therefore offer insights into migration processes not available from classic ...Journal Article -
The equation of motion for supershear frictional rupture fronts
(2018)Science AdvancesThe rupture fronts that mediate the onset of frictional sliding may propagate at speeds below the Rayleigh wave speed or may surpass the shear wave speed and approach the longitudinal wave speed. While the conditions for the transition from sub-Rayleigh to supershear propagation have been studied extensively, little is known about what dictates supershear rupture speeds and how the interplay between the stresses that drive propagation and ...Journal Article -
When Evolution Works Against the Future: Disgust's Contributions to the Acceptance of New Food Technologies
(2019)Risk AnalysisNew food technologies have a high potential to transform the current resource‐consuming food system to a more efficient and sustainable one, but public acceptance of new food technologies is rather low. Such an avoidance might be maintained by a deeply preserved risk avoidance system called disgust. In an online survey, participants (N = 313) received information about a variety of new food technology applications (i.e., genetically ...Journal Article -
A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis
(2020)mAbsColorectal cancer represents the second most common cause of cancer-related death. The human A33 transmembrane glycoprotein is a validated tumor-associated antigen, expressed in 95% of primary and metastatic colorectal cancers. Using phage display technology, we generated a human monoclonal antibody (termed A2) specific to human A33 and we compared its epitope and performance to those of previously described clinical-stage anti-human A33 ...Journal Article -
PaccMann: a web service for interpretable anticancer compound sensitivity prediction
(2020)Nucleic Acids ResearchThe identification of new targeted and personalized therapies for cancer requires the fast and accurate assessment of the drug efficacy of potential compounds against a particular biomolecular sample. It has been suggested that the integration of complementary sources of information might strengthen the accuracy of a drug efficacy prediction model. Here, we present a web-based platform for the Prediction of AntiCancer Compound sensitivity ...Journal Article -
On the Active Vibration Control of Nonlinear Uncertain Structures
(2021)Journal of Applied and Computational MechanicsThis study proposes an active nonlinear control strategy for effective vibration mitigation in nonlinear dynamical systems characterized by uncertainty. The proposed scheme relies on the coupling of a Bayesian nonlinear observer, namely the Unscented Kalman Filter (UKF) with a two-stage control process. The UKF is implemented for adaptive joint state and parameter estimation, with the estimated states and parameters passed onto the ...Journal Article -
3D-Printed Reinforcement Scaffolds with Targeted Biodegradation Properties for the Tissue Engineering of Articular Cartilage
(2021)Advanced Healthcare MaterialsAchieving regeneration of articular cartilage is challenging due to the low healing capacity of the tissue. Appropriate selection of cell source, hydrogel, and scaffold materials are critical to obtain good integration and long-term stability of implants in native tissues. Specifically, biomechanical stability and in vivo integration can be improved if the rate of degradation of the scaffold material matches the stiffening of the sample ...Journal Article -
Models for the n-Swiss Cheese operads
(2021)Transactions of the London Mathematical SocietyWe describe combinatorial Hopf (co-)operadic models for the Swiss Cheese operads built from Feynman diagrams. This extends previous work of Kontsevich and Lambrechts-Voli ' c for the little disks operads.Journal Article