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Digitale Transformation, Patientenorientierung und ethische Ansprüche
(2017)Schweizerische ÄrztezeitungJournal Article -
La mémoire kaléidoscopique: l’histoire au prisme des algorithmes d’autocomplétion
(2019)Geschichte und Informatik = Histoire et informatique ~ Enjeux politiques du web: approches historiques. Das Web als politische Herausforderung: historische PerspektivenJournal Article -
Guilty speculators? Range-based conditional volatility in a cross-section of wheat futures
(2018)Journal of Commodity MarketsIn response to the unusually high levels of price volatility during the world food price crisis of 2007/2008, US and EU regulators have introduced position limits that aim to protect commodity markets from exposure to excess speculation. Such regulatory initiatives presuppose that excess speculation is indeed responsible for excess volatility. Our results debunk this presupposition and show the opposite effect: speculative activity reduces ...Journal Article -
Trading off nutrition and education? A panel data analysis of the dissimilar welfare effects of Organic and Fairtrade standards
(2017)Food PolicyMillions of smallholder farmers in developing countries participate in different types of sustainability standards. A growing body of literature has analyzed the welfare effects, with mixed results. Yet, there are important knowledge gaps. First, most existing studies have looked at the effects of one standard in one country. When comparing between studies it is unclear whether dissimilar outcomes are the result of different standards or ...Journal Article -
La arquitectura en su dimensión temporal
(2017)Bitácora arquitecturaEl tiempo somos nosotros, por lo tanto resulta indispensable hablar de él y comenzar por aquéllos que han pensado en el tiempo a lo largo de la historia desde distintos enfoques. Se reflexionará después sobre los cambios y las posibilidades que puede traer consigo, para concluir con un acercamiento a la arquitectura en su estrecha relación con el tiempo y su “muerte,” la cual se propone contemplar como un ciclo de inicios perpetuos.Journal Article -
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer
(2019)Cell ReportsTumor-associated macrophages (TAMs) represent a major component of the tumor microenvironment supporting tumorigenesis. TAMs re-education has been proposed as a strategy to promote tumor inhibition. However, whether this approach may work in prostate cancer is unknown. Here we find that Pten-null prostate tumors are strongly infiltrated by TAMs expressing C-X-C chemokine receptor type 2 (CXCR2), and activation of this receptor through ...Journal Article -
A Novel Role for Microphthalmia-Associated Transcription Factor–Regulated Pigment Epithelium-Derived Factor during Melanoma Progression
(2015)The American Journal of PathologyMicrophthalmia-associated transcription factor (MITF) acts via pigment epithelium-derived factor (PEDF), an antiangiogenic protein, to regulate retinal pigment epithelium migration. PEDF expression and/or regulation during melanoma development have not been investigated previously. Using immunohistochemistry, we determined expression of PEDF in common and dysplastic melanocytic nevi, melanoma in situ, invasive melanoma, and metastatic ...Journal Article -
Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology
(2015)Cell ReportsToxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation. Most of these toxins interfere with protein translation, but a growing variety of other mechanisms hints at a diversity that is not yet fully appreciated. Here, we characterize a group of FIC domain proteins as toxins of the conserved and abundant FicTA family of TA modules, and we reveal ...Journal Article -
Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity
(2015)Free Radical Biology and MedicineJournal Article -
Estimating the effective elastic modulus and specific fracture energy of snowpack layers from field experiments
(2016)Journal of GlaciologyMeasurements of the mechanical properties of snow are essential for improving our understanding and the prediction of snow failure and hence avalanche release. We performed fracture mechanical experiments in which a crack was initiated by a saw in a weak snow layer underlying cohesive snow slab layers. Using particle tracking velocimetry (PTV), the displacement field of the slab was determined and used to derive the mechanical energy of ...Journal Article