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Soil and Pest Management in French Polynesian Farming Systems and Drivers and Barriers for Implementation of Practices Based on Agroecological Principles
(2021)Frontiers in Sustainable Food SystemsIn the context of climate change, French Polynesia is committed to increasing qualitatively and quantitatively local food production. In this regard, agroecology is perceived as a sustainable pathway to improve farming practices. This article proposes first a theoretical framework to analyze the proximity of farmers' management to agroecological principles. Second, it describes the current use of agroecological pest and soil management ...Journal Article -
Parameter identification for phase-field modeling of fracture: a Bayesian approach with sampling-free update
(2021)Computational MechanicsPhase-field modeling of fracture has gained popularity within the last decade due to the flexibility of the related computational framework in simulating three-dimensional arbitrarily complicated fracture processes. However, the numerical predictions are greatly affected by the presence of uncertainties in the mechanical properties of the material originating from unresolved heterogeneities and the use of noisy experimental data. The ...Journal Article -
Global outsourcing of carbon emissions 1995–2009: A reassessment
(2019)Environmental Science & PolicyIncreasing global production fragmentation allows for outsourcing of emissions, which may undermine national climate policies. Researchers focusing on the gap between consumption-based and production-based emissions have concluded that developed countries are systematically outsourcing emissions to developing countries. However, asymmetries in emissions embodied in trade may emerge due to differences in carbon intensity of energy and ...Journal Article -
Decoupling or delusion? Measuring emissions displacement in foreign trade
(2018)Global Environmental ChangeIn a world where climate goals are global but action remains firmly in the hands of states, reliable methods are needed to ensure that emissions reductions on a national level are not offset by carbon leakage. Appropriate indicators are needed to help policy makers set accurate targets for the carbon balance of their foreign trade and monitor the development of trade in a meaningful way. This paper proposes a new displacement indicator – ...Journal Article -
Privacy-preserving distributed parameter estimation for probability distribution of wind power forecast error
(2021)Renewable EnergyBuilding the conditional probability distribution of wind power forecast errors benefits both wind farms (WFs) and independent system operators (ISOs). Establishing the joint probability distribution of wind power and the corresponding forecast data of spatially correlated WFs is the foundation for deriving the conditional probability distribution. Traditional parameter estimation methods for probability distributions require the collection ...Journal Article -
International Trade and Energy Intensity During European Industrialization, 1870–1935
(2017)Ecological EconomicsPrevious research suggests that there is an inverted U-shape curve for energy intensity in the long-run for Western Europe with a peak in the early 20th century. This paper tests the hypothesis that the increase of German and British energy intensity was an effect from the concentration of heavy industrial production to these countries, although the consumption of a significant share of these goods took place elsewhere. We use an entirely ...Journal Article -
An atlas of human kinase regulation
(2016)Molecular Systems BiologyThe coordinated regulation of protein kinases is a rapid mechanism that integrates diverse cues and swiftly determines appropriate cellular responses. However, our understanding of cellular decision-making has been limited by the small number of simultaneously monitored phospho-regulatory events. Here, we have estimated changes in activity in 215 human kinases in 399 conditions derived from a large compilation of phosphopeptide quantifications. ...Journal Article -
Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses
(2021)Molecular Systems BiologyVarious tools have been recently developed to integrate such datasets, but there are limited strategies to systematically extract mechanistic hypotheses from them. Here, we present COSMOS (Causal Oriented Search of Multi-Omics Space), a method that integrates phosphoproteomics, transcriptomics, and metabolomics datasets. COSMOS combines extensive prior knowledge of signaling, metabolic, and gene regulatory networks with computational ...Journal Article -
Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer
(2017)Cell SystemsCopy-number variations (CNVs) are ubiquitous in cancer and often act as driver events, but the effects of CNVs on the proteome of tumors are poorly understood. Here, we analyze recently published genomics, transcriptomics, and proteomics datasets made available by CPTAC and TCGA consortia on 282 breast, ovarian, and colorectal tumor samples to investigate the impact of CNVs in the proteomes of these cells. We found that CNVs are buffered ...Journal Article -
Sub-minute Phosphoregulation of Cell Cycle Systems during Plasmodium Gamete Formation
(2017)Cell ReportsThe transmission of malaria parasites to mosquitoes relies on the rapid induction of sexual reproduction upon their ingestion into a blood meal. Haploid female and male gametocytes become activated and emerge from their host cells, and the males enter the cell cycle to produce eight microgametes. The synchronized nature of gametogenesis allowed us to investigate phosphorylation signaling during its first minute in Plasmodium berghei via ...Journal Article