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Autonomous Object Manipulation Using a Soft Planar Grasping Manipulator
(2015)Soft RoboticsThis paper presents the development of an autonomous motion planning algorithm for a soft planar grasping manipulator capable of grasp-and-place operations by encapsulation with uncertainty in the position and shape of the object. The end effector of the soft manipulator is fabricated in one piece without weakening seams using lost-wax casting instead of the commonly used multi-layer lamination process. The soft manipulation system can ...Journal Article -
Biogenesis, delivery, and function of extracellular RNA
(2015)Journal of Extracellular VesiclesThe Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the mechanisms for the delivery and uptake by ...Journal Article -
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REDEMPTION: reduced dimension ensemble modeling and parameter estimation
(2015)BioinformaticsJournal Article -
Cross-disciplinary research: What configurations of fields of science are found in grant proposals today?
(2015)Research EvaluationJournal Article -
Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells
(2015)Nucleic Acids ResearchMicroRNAs (miRNAs) originate from stem-loop-containing precursors (pre-miRNAs, pri-miRNAs) and mature by means of the Drosha and Dicer endonucleases and their associated factors. The let-7 miRNAs have prominent roles in developmental differentiation and in regulating cell proliferation. In cancer, the tumor suppressor function of let-7 is abrogated by overexpression of Lin28, one of several RNA-binding proteins that regulate let-7 biogenesis ...Journal Article -
How to assess the effectiveness of development aid projects: evaluation ratings versus project indicators
(2015)Journal of International DevelopmentMost studies on project-based aid effectiveness rely on subjective evaluation ratings to measure projects' performance. Using the example of drinking water projects, this study compares evaluation ratings to objective, quantitative project indicators based on water supply to better understand the drivers of evaluation ratings. We find that evaluation ratings are only weakly correlated with improvements in water supply. Whereas the water ...Journal Article -
Cross-resistance to QoI fungicides azoxystrobin and pyraclostrobin in the wheat blast pathogen Pyricularia oryzae in Brazil
(2015)Summa PhytopathologicaAs estrobilurinas estão entre os fungicidas mais comumente utilizados no controle das doenças do trigo, isoladamente ou em misturas com fungicidas inibidores da enzima succinato desidrogenase (IDHS). As estrobilurinas são conhecidas como fungicidas inibidores da quinona oxidase ou fungicidas IQo. Por ter como alvo um único sítio de ação nas células fúngicas, o gene mitocondrial cyt b, o emprego contínuo das estrobilurinas pode representar ...Journal Article -
Properties of short double-stranded RNAs carrying randomized base pairs: Toward better controls for RNAi experiments
(2015)RNAShort interfering RNAs (siRNAs) are mediators of RNA interference (RNAi), a commonly used technique for selective down-regulation of target gene expression. Using an equimolar mixture of A, G, C, and U phosphoramidites during solid-phase synthesis, we introduced degenerate positions into RNA guide and passenger strands so that, when annealed, a large pool of distinct siRNA duplexes with randomized base pairs at defined sites was created. ...Journal Article -
Whole-genome mapping of 5′ RNA ends in bacteria by tagged sequencing: A comprehensive view in Enterococcus faecalis
(2015)RNAEnterococcus faecalis is the third cause of nosocomial infections. To obtain the first snapshot of transcriptional organizations in this bacterium, we used a modified RNA-seq approach enabling to discriminate primary from processed 5′ RNA ends. We also validated our approach by confirming known features in Escherichia coli. We mapped 559 transcription start sites (TSSs) and 352 processing sites (PSSs) in E. faecalis. A blind motif search ...Journal Article