Search
Results
-
Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis
(2020)NeuroImageJournal Article -
Listvenite Formation During Mass Transfer into the Leading Edge of the Mantle Wedge: Initial Results from Oman Drilling Project Hole BT1B
(2022)Journal of Geophysical Research: Solid EarthThis paper provides an overview of research on core from Oman Drilling Project Hole BT1B and the surrounding area, plus new data and calculations, constraining processes in the Tethyan subduction zone beneath the Samail ophiolite. The area is underlain by gently dipping, broadly folded layers of allochthonous Hawasina pelagic sediments, the metamorphic sole of the Samail ophiolite, and Banded Unit peridotites at the base of the Samail ...Journal Article -
Deep Sourced Fluids for Peridotite Carbonation in the Shallow Mantle Wedge of a Fossil Subduction Zone: Sr and C Isotope Profiles of OmanDP Hole BT1B
(2022)Journal of Geophysical Research: Solid EarthCompletely carbonated peridotites represent a window to study reactions of carbon-rich fluids with mantle rocks. Here, we present details on the carbonation history of listvenites close to the basal thrust in the Samail ophiolite. We use samples from Oman Drilling Project Hole BT1B, which provides a continuous record of lithologic transitions, as well as outcrop samples from listvenites, metasediments, and metamafics below the basal thrust ...Journal Article -
Dark Energy Survey Year 1 Results: Cosmological Constraints from Cluster Abundances, Weak Lensing, and Galaxy Correlations
(2021)Physical Review LettersWe present the first joint analysis of cluster abundances and auto or cross-correlations of three cosmic tracer fields: galaxy density, weak gravitational lensing shear, and cluster density split by optical richness. From a joint analysis (4×2pt+N) of cluster abundances, three cluster cross-correlations, and the auto correlations of the galaxy density measured from the first year data of the Dark Energy Survey, we obtain Ωm=0.305+0.055−0.038 ...Journal Article -
The all-sky PLATO input catalogue
(2021)Astronomy & AstrophysicsContext. The ESA PLAnetary Transits and Oscillations of stars (PLATO) mission will search for terrestrial planets in the habitable zone of solar-type stars. Because of telemetry limitations, PLATO targets need to be pre-selected. Aims. In this paper, we present an all sky catalogue that will be fundamental to selecting the best PLATO fields and the most promising target stars, deriving their basic parameters, analysing the instrumental ...Journal Article -
Multiscale PHATE identifies multimodal signatures of COVID-19
(2022)Nature BiotechnologyAs the biomedical community produces datasets that are increasingly complex and high dimensional, there is a need for more sophisticated computational tools to extract biological insights. We present Multiscale PHATE, a method that sweeps through all levels of data granularity to learn abstracted biological features directly predictive of disease outcome. Built on a coarse-graining process called diffusion condensation, Multiscale PHATE ...Journal Article -
Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders
(2022)Cancer DiscoveryPersonalized medicine aims to match the right drug with the right patient by using specific features of the individual patient’s tumor. However, current strategies of personalized therapy matching provide treatment opportunities for less than 10% of patients with cancer. A promising method may be drug profiling of patient biopsy specimens with single-cell resolution to directly quantify drug effects. We prospectively tested an image-based ...Journal Article -
The origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 in the UK
(2022)Virus EvolutionThe first SARS-CoV-2 variant of concern (VOC) to be designated was lineage B.1.1.7, later labelled by the World Health Organization as Alpha. Originating in early autumn but discovered in December 2020, it spread rapidly and caused large waves of infections worldwide. The Alpha variant is notable for being defined by a long ancestral phylogenetic branch with an increased evolutionary rate, along which only two sequences have been sampled. ...Journal Article -
STIX X-ray microflare observations during the Solar Orbiter commissioning phase
(2021)Astronomy & AstrophysicsContext. The Spectrometer/Telescope for Imaging X-rays (STIX) is the hard X-ray instrument onboard Solar Orbiter designed to observe solar flares over a broad range of flare sizes. Aims. We report the first STIX observations of solar microflares recorded during the instrument commissioning phase in order to investigate the STIX performance at its detection limit. Methods. STIX uses hard X-ray imaging spectroscopy in the range between 4-150 ...Journal Article -
Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people
(2022)Proceedings of the National Academy of Sciences of the United States of AmericaThe use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to 80% depending on the trait. The genetic architecture is complex, heterogeneous, and multifactorial, but investigations of contributions of single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present a ...Journal Article