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Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases
(2009)The EMBO JournalJournal Article -
Spatial variation of microtubule depolymerization in large asters
(2021)Molecular Biology of the CellMicrotubule plus-end depolymerization rate is a potentially important target of physiological regulation, but it has been challenging to measure, so its role in spatial organization is poorly understood. Here we apply a method for tracking plus ends based on time difference imaging to measure depolymerization rates in large interphase asters growing in Xenopus egg extract. We observed strong spatial regulation of depolymerization rates, ...Journal Article -
Nanoscopic compartmentalization of membrane protein motion at the axon initial segment
(2016)The Journal of Cell BiologyThe axon initial segment (AIS) is enriched in specific adaptor, cytoskeletal, and transmembrane molecules. During AIS establishment, a membrane diffusion barrier is formed between the axonal and somatodendritic domains. Recently, an axonal periodic pattern of actin, spectrin, and ankyrin forming 190-nm-spaced, ring-like structures has been discovered. However, whether this structure is related to the diffusion barrier function is unclear. ...Journal Article -
Evolution and functional cross-talk of protein post-translational modifications
(2013)Molecular Systems BiologyProtein post-translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTMs and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of the evolution and function of PTMs that were ...Journal Article -
Combination of temozolomide with immunocytokine F16-IL2 for the treatment of glioblastoma
(2010)British Journal of CancerBackground: Glioblastoma patients are still not cured by the treatments available at the moment. We investigated the therapeutic properties of temozolomide in combination with F16–IL2, a clinical-stage immunocytokine consisting of human interleukin (IL)-2 fused to the human antibody F16, specific to the A1 domain of tenascin-C. Methods: We conducted three preclinical therapy studies, using subcutaneous and intracranial U87MG glioblastoma ...Journal Article -
Helsingør Statement on poly- and perfluorinated alkyl substances (PFASs)
(2014)ChemosphereIn this discussion paper, the transition from long-chain poly- and perfluorinated alkyl substances (PFASs) to fluorinated alternatives is addressed. Long-chain PFASs include perfluoroalkyl carboxylic acids (PFCAs) with 7 or more perfluorinated carbons, perfluoroalkyl sulfonic acids (PFSAs) with 6 or more perfluorinated carbons, and their precursors. Because long-chain PFASs have been found to be persistent, bioaccumulative and toxic, they ...Journal Article -
Potential release scenarios for carbon nanotubes used in composites
(2013)Environment InternationalThe expected widespread use of carbon nanotube (CNT)-composites in consumer products calls for an assessment of the possible release and exposure to workers, consumers and the environment. Release of CNTs may occur at all steps in the life cycle of products, but to date only limited information is available about release of CNTs from actual products and articles. As a starting point for exposure assessment, exploring sources and pathways ...Journal Article -
The in situ structures of mono-, di-, and trinucleosomes in human heterochromatin
(2018)Molecular Biology of the CellThe in situ three-dimensional organization of chromatin at the nucleosome and oligonucleosome levels is unknown. Here we use cryo-electron tomography to determine the in situ structures of HeLa nucleosomes, which have canonical core structures and asymmetric, flexible linker DNA. Subtomogram remapping suggests that sequential nucleosomes in heterochromatin follow irregular paths at the oligonucleosome level. This basic principle of ...Journal Article -
Temporal differences in plant growth and root exudation of two Brachiaria grasses in response to low phosphorus supply
(2017)Tropical Grasslands - Forrajes TropicalesExploiting the natural variability of Brachiaria forage germplasm to identify forage grasses adapted to infertile acid soils that contain very low available phosphorus (P) is an important research objective for improving livestock production in the tropics. The objective of this study was to determine the differences in the release of root biochemical markers, i.e. carboxylates and acid phosphatases (APases), during the development of P ...Journal Article -
Highly recombinant VGII Cryptococcus gattii population develops clonal outbreak clusters through both sexual macroevolution and asexual microevolution
(2014)mBioAn outbreak of the fungal pathogen Cryptococcus gattii began in the Pacific Northwest (PNW) in the late 1990s. This outbreak consists of three clonal subpopulations: VGIIa/major, VGIIb/minor, and VGIIc/novel. Both VGIIa and VGIIc are unique to the PNW and exhibit increased virulence. In this study, we sequenced the genomes of isolates from these three groups, as well as global isolates, and analyzed a total of 53 isolates. We found that ...Journal Article