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Hydrological processes in regional climate model simulations of the central United States flood of June-July 1993
(2003)Journal of HydrometeorologyJournal Article -
Changes in European summer temperature variability revisited
(2012)Geophysical Research LettersJournal Article -
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
(2012)Proceedings of the National Academy of Sciences of the United States of AmericaJournal Article -
Nuclear Properties of a Sample of Nearby Spiral Galaxies from Hubble Space Telescope STIS Imaging
(2004)The Astronomical JournalJournal Article -
Multisite spectroscopic seismic study of the β Cep star V2052 Ophiuchi: Inhibition of mixing by its magnetic field
(2012)Monthly Notices of the Royal Astronomical SocietyJournal Article -
Controlled Breast Cancer Microarrays for the Deconvolution of Cellular Multilayering and Density Effects upon Drug Responses
(2012)PLoS ONEBackground Increasing evidence shows that the cancer microenvironment affects both tumorigenesis and the response of cancer to drug treatment. Therefore in vitro models that selectively reflect characteristics of the in vivo environment are greatly needed. Current methods allow us to screen the effect of extrinsic parameters such as matrix composition and to model the complex and three-dimensional (3D) cancer environment. However, 3D ...Journal Article -
Analysis of the Subunit Stoichiometries in Viral Entry
(2012)PLoS ONEVirions of the Human Immunodeficiency Virus (HIV) infect cells by first attaching with their surface spikes to the CD4 receptor on target cells. This leads to conformational changes in the viral spikes, enabling the virus to engage a coreceptor, commonly CCR5 or CXCR4, and consecutively to insert the fusion peptide into the cellular membrane. Finally, the viral and the cellular membranes fuse. The HIV spike is a trimer consisting of three ...Journal Article -
Dynamic Interaction of cBid with Detergents, Liposomes and Mitochondria
(2012)PLoS ONEThe BH3-only protein Bid plays a key role in the induction of mitochondrial apoptosis, but its mechanism of action is still not completely understood. Here we studied the two main activation events of Bid: Caspase-8 cleavage and interaction with the membrane bilayer. We found a striking reversible behaviour of the dissociation-association events between the Bid fragments p15 and p7. Caspase-8 cleavage does not induce per se separation of ...Journal Article -
Integrative genome-wide expression profiling identifies three distinct molecular subgroups of renal cell carcinoma with different patient outcome
(2012)BMC CancerBackground Renal cell carcinoma (RCC) is characterized by a number of diverse molecular aberrations that differ among individuals. Recent approaches to molecularly classify RCC were based on clinical, pathological as well as on single molecular parameters. As a consequence, gene expression patterns reflecting the sum of genetic aberrations in individual tumors may not have been recognized. In an attempt to uncover such molecular features ...Journal Article