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Dark Matter benchmark models for early LHC Run-2 Searches: Report of the ATLAS/CMS Dark Matter Forum
(2020)Physics of the Dark UniverseThis document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of the parameter space of these models and a ...Journal Article -
Clonal fitness inferred from time-series modelling of single-cell cancer genomes
(2021)NatureProgress in defining genomic fitness landscapes in cancer, especially those defined by copy number alterations (CNAs), has been impeded by lack of time-series single-cell sampling of polyclonal populations and temporal statistical models1-7. Here we generated 42,000 genomes from multi-year time-series single-cell whole-genome sequencing of breast epithelium and primary triple-negative breast cancer (TNBC) patient-derived xenografts (PDXs), ...Journal Article -
Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set
(2019)Nature CommunicationsThe current wealth of genomic variation data identified at nucleotide level presents the challenge of understanding by which mechanisms amino acid variation affects cellular processes. These effects may manifest as distinct phenotypic differences between individuals or result in the development of disease. Physical interactions between molecules are the linking steps underlying most, if not all, cellular processes. Understanding the effects ...Journal Article -
DNAqua-Net: Developing new genetic tools for bioassessment and monitoring of aquatic ecosystems in Europe
(2016)Research Ideas and OutcomesThe protection, preservation and restoration of aquatic ecosystems and their functions are of global importance. For European states it became legally binding mainly through the EU-Water Framework Directive (WFD). In order to assess the ecological status of a given water body, aquatic biodiversity data are obtained and compared to a reference water body. The quantified mismatch obtained determines the extent of potential management actions. ...Journal Article -
A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals
(2023)Nature Biomedical EngineeringFully implantable wireless systems for the recording and modulation of neural circuits that do not require physical tethers or batteries allow for studies that demand the use of unconstrained and freely behaving animals in isolation or in social groups. Moreover, feedback-control algorithms that can be executed within such devices without the need for remote computing eliminate virtual tethers and any associated latencies. Here we report ...Journal Article -
International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass
(2020)Journal of Hospital InfectionJournal Article -
HESS Observations of the Prompt and Afterglow Phases of GRB 060602B
(2009)The Astrophysical JournalJournal Article -
Radio Antenna Design for Sky-Averaged 21cm Cosmology Experiments: The REACH Case
(2022)Journal of Astronomical InstrumentationFollowing the reported detection of an absorption profile associated with the 21 cm sky-averaged signal from the Cosmic Dawn by the EDGES experiment in 2018, a number of experiments have been set up to verify this result. This paper discusses the design process used for global 21cm experiments, focusing specifically on the Radio Experiment for the Analysis of Cosmic Hydrogen (REACH). This experiment will seek to understand and compensate ...Journal Article -
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Search for strange-pentaquark production in e(+)e(-) annihilation at √s=10.58 GeV
(2005)Physical Review LettersJournal Article