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Fast estimation of the difference between two PAM/JTT evolutionary distances in triplets of homologous sequences
(2006)BMC BioinformaticsBackground The estimation of the difference between two evolutionary distances within a triplet of homologs is a common operation that is used for example to determine which of two sequences is closer to a third one. The most accurate method is currently maximum likelihood over the entire triplet. However, this approach is relatively time consuming. Results We show that an alternative estimator, based on pairwise estimates and therefore ...Journal Article -
Algorithm of OMA for large-scale orthology inference
(2008)BMC BioinformaticsBackground OMA is a project that aims to identify orthologs within publicly available, complete genomes. With 657 genomes analyzed to date, OMA is one of the largest projects of its kind. Results The algorithm of OMA improves upon standard bidirectional best-hit approach in several respects: it uses evolutionary distances instead of scores, considers distance inference uncertainty, includes many-to-many orthologous relations, and ...Journal Article