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Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines
(2019)iScienceHere we describe a proteomic data resource for the NCI-60 cell lines generated by pressure cycling technology and SWATH mass spectrometry. We developed the DIA-expert software to curate and visualize the SWATH data, leading to reproducible detection of over 3,100 SwissProt proteotypic proteins and systematic quantification of pathway activities. Stoichiometric relationships of interacting proteins for DNA replication, repair, the chromatin ...Journal Article -
Immunization of cats to induce neutralizing antibodies against Fel d 1, the major feline allergen in human subjects
(2019)Journal of Allergy and Clinical ImmunologyBackground Cat allergy in human subjects is usually caused by the major cat allergen Fel d 1 and is found in approximately 10% of the Western population. Currently, there is no efficient and safe therapy for cat allergy available. Allergic patients usually try to avoid cats or treat their allergy symptoms. Objective We developed a new strategy to treat Fel d 1–induced allergy in human subjects by immunizing cats against their own ...Journal Article -
Derivation of Haploid Trophoblast Stem Cells via Conversion In Vitro
(2019)iScienceOwing to their single genome, haploid cells are powerful to uncover unknown genes by performing genetic screening in mammals. However, no haploid cell line from an extraembryonic lineage has been achieved yet, which limits the application of haploid cells in placental genetic screening. Here, we show that overexpression of Cdx2 can convert haploid embryonic stem cells to trophoblast stem cells (TSCs). p53 deletion reduces diploidization ...Journal Article -
Fate Distribution and Regulatory Role of Human Mesenchymal Stromal Cells in Engineered Hematopoietic Bone Organs
(2019)iScienceThe generation of humanized ectopic ossicles (hOss) in mice has been proposed as an advanced translational and fundamental model to study the human hematopoietic system. The approach relies on the presence of human bone marrow-derived mesenchymal stromal cells (hMSCs) supporting the engraftment of transplanted human hematopoietic stem and progenitor cells (HSPCs). However, the functional distribution of hMSCs within the humanized ...Journal Article -
Creating an Interface: Rendering a Double-Network Hydrogel Lubricious via Spontaneous Delamination
(2019)ACS Applied Materials & InterfacesHydrogels engineered with specific surface chemistries and architectures have found myriad applications in electronics, biofouling, biolubrication, and biomedical devices. Free-radical polymerization is frequently employed to construct covalently bonded networks in hydrogels, and any inhibition of the radical reactions by oxygen at the surface of the reaction mixture is generally undesirable. The internal stress caused by the resulting ...Journal Article -
Assessment of spatial variability of multiple ecosystem services in grasslands of different intensities
(2019)Journal of Environmental ManagementJournal Article -
High-resolution Cd isotope systematics in multiple zones of the Southern Ocean from the Antarctic Circumnavigation Expedition
(2019)Earth and Planetary Science LettersJournal Article -
Morphology development in single drop drying for native and aggregated whey protein dispersions
(2019)Colloids and Surfaces A: Physicochemical and Engineering AspectsNative and aggregated whey proteins (WP) are used in food and pharmaceutical applications as stabilizers, thickeners and carriers. For increasing shelf-life and facilitating transportation, WP are transformed into powders by spray-drying. Powder functional properties strongly depend on the final particle morphology. Focusing on colloidal aspects of drying, the goal of this work is to: (i) investigate morphology development during single ...Journal Article -
Display clutter and its effects on visual attention distribution and financial risk judgment
(2019)Applied ErgonomicsDisplay clutter is a widely studied phenomenon in ergonomics, where information density and other properties of task-relevant visualizations are related to effective user performance and visual attention. This paper examines the impact of clutter in the context of financial stock visualizations. Depending on their expertise, traders can use a variety of different cues to judge the current and future value of a stock and to assess its ...Journal Article