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Supraglacial ice cliffs and ponds on debris-covered glaciers: spatio-temporal distribution and characteristics
(2019)Journal of GlaciologyIce cliffs and ponds on debris-covered glaciers have received increased attention due to their role in amplifying local melt. However, very few studies have looked at these features on the catchment scale to determine their patterns and changes in space and time. We have compiled a detailed inventory of cliffs and ponds in the Langtang catchment, central Himalaya, from six high-resolution satellite orthoimages and DEMs between 2006 and ...Journal Article -
Generalized size scaling of metabolic rates based on single-cell measurements with freshwater phytoplankton
(2019)Proceedings of the National Academy of Sciences of the United States of AmericaKleiber’s law describes the scaling of metabolic rate with body size across several orders of magnitude in size and across taxa and is widely regarded as a fundamental law in biology. The physiological origins of Kleiber’s law are still debated and generalizations of the law accounting for deviations from the scaling behavior have been proposed. Most theoretical and experimental studies of Kleiber’s law, however, have focused on the ...Journal Article -
Long-term outdoor lysimeter study with cerium dioxide nanomaterial
(2019)NanoImpactFate and impact of cerium dioxide nanomaterials (CeO2 NM) in soil remains uncertain. Most of the recent environmental studies used high doses of CeO2 NM in short-term laboratory experiments and stated soil as large sink for NM. Recent studies covering the life cycle of plants found evidence for particle uptake in crop plants, and triggered concern about NM entering the food chain. Here, we present a 25 months outdoor lysimeter study that ...Journal Article -
A national wastewater monitoring program for a better understanding of public health: a case study using the Australian census.
(2019)Environment InternationalWastewater contains a large range of biological and chemical markers of human activity and exposures. Through systematic collection and analysis of these markers within wastewater samples it is possible to measure the public health of whole populations. The analysis of effluent and biosolids can also be used to understand the release of chemicals from wastewater treatment plants into the environment. Wastewater analysis and comparison ...Journal Article -
Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments
(2019)The EMBO JournalThe DNA damage response (DDR) generates transient repair compartments to concentrate repair proteins and activate signaling factors. The physicochemical properties of these spatially confined compartments and their function remain poorly understood. Here, we establish, based on live cell microscopy and CRISPR/Cas9‐mediated endogenous protein tagging, that 53BP1‐marked repair compartments are dynamic, show droplet‐like behavior, and undergo ...Journal Article -
Coupled simulation of thermally active building systems to support a digital twin
(2019)Energy and BuildingsBased on 2050 Swiss and European Union targets, significant energy performance improvements will be required for new and renovated buildings. However, the construction industry has a poor record for delivering productivity and efficiency advancement. As proven in other industries, digital methods can shorten product development time and cost by reducing prototyping with the use of numerical simulation. Further, a digital twin is an extensive ...Journal Article -
Population-based inference of aminoglycoside resistance mechanisms in Escherichia coli
(2019)eBioMedicineBackground Interpretative reading of antimicrobial susceptibility test (AST) results allows inferring biochemical resistance mechanisms from resistance phenotypes. For aminoglycosides, however, correlations between resistance pathways inferred on the basis of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoints and expert rules versus genotypes are generally poor. This study aimed at developing and ...Journal Article -
Melt-Induced Fractionation of Major Ions and Trace Elements in an Alpine Snowpack
(2019)Journal of Geophysical Research: Earth SurfaceUnderstanding the impact of melting on the preservation of atmospheric compounds in high‐Alpine snow and glacier ice is crucial for future reconstruction of past atmospheric conditions. However, detailed studies investigating melt‐related changes of such proxy information are rare. Here we present a series of five snow pit profiles of 6 major ions and 34 trace elements at Weissfluhjoch, Switzerland, collected between January and June 2017. ...Journal Article -
No evidence of differences in cognitive control in children with autism spectrum disorder or obsessive-compulsive disorder: An fMRI study
(2019)Developmental Cognitive NeuroscienceRepetitive behaviors are among the core symptoms of both Autism Spectrum Disorder (ASD) and Obsessive-Compulsive Disorder (OCD) and are thought to be associated with impairments in cognitive control. However, it is still unknown how deficits in cognitive control and associated neural circuitry relate to the quality or severity of repetitive behavior in children with these disorders. Therefore, we investigated the behavioral and neural ...Journal Article -
Multiradionuclide evidence for an extreme solar proton event around 2,610 BP (similar to 660 BC)
(2019)Proceedings of the National Academy of Sciences of the United States of AmericaRecently, it has been confirmed that extreme solar proton events can lead to significantly increased atmospheric production rates of cosmogenic radionuclides. Evidence of such events is recorded in annually resolved natural archives, such as tree rings [carbon-14 (14C)] and ice cores [beryllium-10 (10Be), chlorine-36 (36Cl)]. Here, we show evidence for an extreme solar event around 2,610 years B.P. (∼660 BC) based on high-resolution 10Be ...Journal Article