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Distribution and diversity of ‘Tectomicrobia’, a deep-branching uncultivated bacterial lineage harboring rich producers of bioactive metabolites
(2023)ISME CommunicationsGenomic and functional analyses of bacterial sponge symbionts belonging to the uncultivated candidate genus ‘Entotheonella’ has revealed them as the prolific producers of bioactive compounds previously identified from their invertebrate hosts. These studies also suggested ‘Entotheonella’ as the first members of a new candidate phylum, ‘Tectomicrobia’. Here we analyzed the phylogenetic structure and environmental distribution of this as-yet ...Journal Article -
It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
(2018)Open BiologyAmong cyclic nucleotide phosphodiesterases (PDEs), PDE6 is unique in serving as an effector enzyme in G protein-coupled signal transduction. In retinal rods and cones, PDE6 is membrane-bound and activated to hydrolyse its substrate, cGMP, by binding of two active G protein α-subunits (Gα*). To investigate the activation mechanism of mammalian rod PDE6, we have collected functional and structural data, and analysed them by reaction–diffusion ...Journal Article -
Roadmap on the use of artificial intelligence for imaging of vulnerable atherosclerotic plaque in coronary arteries
(2024)Nature Reviews CardiologyArtificial intelligence (AI) is likely to revolutionize the way medical images are analysed and has the potential to improve the identification and analysis of vulnerable or high-risk atherosclerotic plaques in coronary arteries, leading to advances in the treatment of coronary artery disease. However, coronary plaque analysis is challenging owing to cardiac and respiratory motion, as well as the small size of cardiovascular structures. ...Journal Article -
Numerical investigation of a film-cooling flow structure: effect of crossflow turbulence
(2013)Journal of TurbomachineryNumerical simulation results using large-eddy simulation of a flow configuration relevant to the film cooling of turbine blades are presented. The flow configuration and the simulation parameters are chosen according to an experiment from literature, in which a hot turbulent crossflow over a flat plate is cooled by fluid issuing from a large isobaric plenum through a short inclined circular nozzle. Special attention is paid to the flow ...Journal Article -
Identifying Mechanisms Behind the Tullio Phenomenon: a Computational Study Based on First Principles
(2016)Journal of the Association for Research in Otolaryngology (JARO)Patients with superior canal dehiscence (SCD) suffer from events of dizziness and vertigo in response to sound, also known as Tullio phenomenon (TP). The present work seeks to explain the fluid-dynamical mechanisms behind TP. In accordance with the so-called third window theory, we developed a computational model for the vestibular signal pathway between stapes and SCD. It is based on first principles and accounts for fluid–structure ...Journal Article -
Transition to turbulence and noise radiation in heated coaxial jet flows
(2016)Physics of FluidsLaminar-turbulent transition and noise radiation of a parametrized set of subsonic coaxial jet flows with a hot primary (core) stream are investigated numerically by Large-Eddy Simulation (LES) and direct noise computation. This study extends our previous research on local linear stability of heated coaxial jet flows by analyzing the nonlinear evolution of initially laminar flows disturbed by a superposition of small-amplitude unstable ...Journal Article -
Nanodroplet Flight Control in Electrohydrodynamic Redox 3D Printing
(2024)ACS Applied Materials & InterfacesElectrohydrodynamic 3D printing is an additive manufacturing technique with enormous potential in plasmonics, microelectronics, and sensing applications thanks to its broad material palette, high voxel deposition rate, and compatibility with various substrates. However, the electric field used to deposit material is concentrated at the depositing structure, resulting in the focusing of the charged droplets and geometry-dependent landing ...Journal Article -
Vorticity flux control for a turbulent channel flow
(1999)Physics of FluidsA feedback control algorithm using wall only information has been applied in simulations of low Reynolds number (Reτ=180) turbulent channel flow. The present control scheme is based on the manipulation of the vorticity flux components, which can be obtained as a function of time by measuring the instantaneous pressure at the wall and calculating its gradient. The strength of the unsteady mass transpiration actuators can be derived explicitly ...Journal Article -
Variational Classification: A Probabilistic Generalization of the Softmax Classifier
(2023)Transactions on Machine Learning ResearchWe present a latent variable model for classification that provides a novel probabilistic interpretation of neural network softmax classifiers. We derive a variational objective to train the model, analogous to the evidence lower bound (ELBO) used to train variational auto-encoders, that generalises the softmax cross-entropy loss. Treating inputs to the softmax layer as samples of a latent variable, our abstracted perspective reveals a ...Journal Article -
Film Cooling Using Antikidney Vortex Pairs: Effect of Blowing Conditions and Yaw Angle on Cooling and Losses
(2014)Journal of TurbomachineryA film-cooling configuration generating an antikidney vortex pair is studied. The configuration features cylindrical cooling holes inclined at an angle of α = 35 deg and arranged in two spanwise rows with row-wise alternating yaw angles ±β. Results of several largeeddy simulations are presented with varying blowing conditions and yaw angles. The effects on the achieved cooling and the generated losses are studied. The film-cooling Reynolds ...Journal Article