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m-nitrobenzyl alcohol supercharging reagent enhances the chromatographic separation and the charging of disulfide bond linked and His-tag peptides
(2024)Journal of Chromatography AThe linkages of disulfide bond (DSB) play important roles in protein stability and activity. Mass spectrometry-based (MS-based) techniques become accepted tools for DSB analysis in the recent decade. In the bottom-up approach, after enzyme digestion, the neighbouring amino acids of cysteines have great impacts on the physicochemical properties of resulting disulfide bond peptides, determining their retention behaviour on liquid chromatography ...Journal Article -
On-Command Disassembly of Microrobotic Superstructures for Transport and Delivery of Magnetic Micromachines
(2024)Advanced MaterialsMagnetic microrobots have been developed for navigating microscale environments by means of remote magnetic fields. However, limited propulsion speeds at small scales remain an issue in the maneuverability of these devices as magnetic force and torque are proportional to their magnetic volume. Here, a microrobotic superstructure is proposed, which, as analogous to a supramolecular system, consists of two or more microrobotic units that ...Journal Article -
Enhanced prediction of vegetation responses to extreme drought using deep learning and Earth observation data
(2024)Ecological InformaticsThe advent of abundant Earth observation data enables the development of novel predictive methods for forecasting climate impacts on the state and health of terrestrial ecosystems. Here, we predict the spatial and temporal variations of land surface reflectance and vegetation greenness, measuring the density of green vegetation and active foliage area, conditioned on current and past weather and the local topography. We train two alternative ...Journal Article -
A structure-preserving machine learning framework for accurate prediction of structural dynamics for systems with isolated nonlinearities
(2024)Mechanical Systems and Signal ProcessingThe nonlinearities present in structural systems are often found in isolated regions within the structure, such as those containing joints or interfaces. However, despite the localized nature of these nonlinearities their presence serves to couple together the modes of the underlying linear system and significantly complicate the development of appropriate reduced-order models; the localized nonlinearities have a global effect on the ...Journal Article -
Contrasting physiological strategies explain heterogeneous responses to severe drought conditions within local populations of a widespread conifer
(2024)Science of The Total EnvironmentUnderstanding how trees prioritize carbon gain at the cost of drought vulnerability under severe drought conditions is crucial for predicting which genetic groups and individuals will be resilient to future climate conditions. In this study, we investigated variations in growth, tree-ring anatomy as well as carbon and oxygen isotope ratios to assess the sensitivity and the xylem formation process in response to an episode of severe drought ...Journal Article -
On the palm oil-biodiversity trade-off: Environmental performance of smallholder producers
(2024)Journal of Environmental Economics and ManagementOil palm remains an important source of rural income in South East Asia. At the same time, Indonesia has become a hotspot for large-scale species extinction and a loss of biodiversity in favor of agricultural production. The present study sets out to assess the environmental performance of smallholder oil palm production with respect to biodiversity. Using a panel dataset that combines conventional farm data together with an account of ...Journal Article -
Farm‐level responses to weather trends: A structural model
(2024)American Journal of Agricultural EconomicsAssessing the effects of weather and climate on agricultural production is crucial for designing policies related to climate change adaptation and mitigation. A large body of literature has identified the detrimental effects of climate change on crop yields worldwide, and farm-level adaptation has been shown to mitigate the adverse effects on agricultural production. In this study, we employ a structural model to examine farm production ...Journal Article -
Development of water management strategies in southern Mesopotamia during the fourth and third millennium BCE
(2024)GeoarchaeologyThe last two decades witnessed increasing scholarly interest in the history of water management in southern Mesopotamia. Thanks to many geoarchaeological research projects conducted throughout the central and southern Iraqi floodplains, a general understanding of the macrophases of anthropogenic manipulation of this vast hydraulic landscape has been achieved. However, current narratives mostly rely on studies at a regional scale and are ...Journal Article -
Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction
(2024)Cancer LettersInhibition of K-RAS effectors like B-RAF or MEK1/2 is accompanied by treatment resistance in cancer patients via re-activation of PI3K and Wnt signaling. We hypothesized that myotubularin-related-protein-7 (MTMR7), which inhibits PI3K and ERK1/2 signaling downstream of RAS, directly targets RAS and thereby prevents resistance. Using cell and structural biology combined with animal studies, we show that MTMR7 binds and inhibits RAS at ...Journal Article -
The chemistry of disorazoles and structure-activity relationships: An update
(2024)TetrahedronThe disorazoles are a family of 26- to 32-membered macrodiolides of mixed non-ribosomal peptide and polyketide origin that show exceptional cytotoxic activity. Of the 39 different disorazoles that have been isolated so far, total syntheses have been described for three family members, namely the non-symmetrical disorazole A1 and the symmetrical disorazoles B1 and C1. With the exception of the first total synthesis of disorazole C1, these ...Journal Article