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Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis
(2009)CellDysfunction and loss of insulin-producing pancreatic β cells represent hallmarks of diabetes mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38δ display improved glucose tolerance due to enhanced insulin secretion from pancreatic β cells. Deletion of p38δ results in pronounced activation of protein kinase D (PKD), the latter of which we have identified as a pivotal regulator of stimulated insulin ...Journal Article -
Pancreatic Cancer Proteome: The Proteins That Underlie Invasion, Metastasis, and Immunologic Escape
(2005)GastroenterologyBackground & Aims: Pancreatic cancer is a highly lethal disease that has seen little headway in diagnosis and treatment for the past few decades. The effective treatment of pancreatic cancer is critically relying on the diagnosis of the disease at an early stage, which still remains challenging. New experimental approaches, such as quantitative proteomics, have shown great potential for the study of cancer and have opened new opportunities ...Journal Article -
Proteome analysis of legionella vacuoles purified by magnetic immunoseparation reveals secretory and endosomal GTPases
(2009)Traffic : the international journal of intracellular transportJournal Article