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Methylofuran is a prosthetic group of the formyltransferase/hydrolase complex and shuttles one-carbon units between two active sites
(2019)Proceedings of the National Academy of Sciences of the United States of AmericaMethylotrophy, the ability of microorganisms to grow on reduced one-carbon substrates such as methane or methanol, is a feature of various bacterial species. The prevailing oxidation pathway depends on tetrahydromethanopterin (H4MPT) and methylofuran (MYFR), an analog of methanofuran from methanogenic archaea. Formyltransferase/hydrolase complex (Fhc) generates formate from formyl-H4MPT in two consecutive reactions where MYFR acts as a ...Journal Article -
Physical and biogeochemical controls on the distribution of dissolved cadmium and its isotopes in the Southwest Pacific Ocean
(2019)Chemical GeologyJournal Article -
How to consider fractional counting and field normalization in the statistical modeling of bibliometric data: A multilevel Poisson regression approach
(2019)Journal of InformetricsThe numerical-algorithmic procedures of fractional counting and field normalization are often mentioned as indispensable requirements for bibliometric analyses. Against the background of the increasing importance of statistics in bibliometrics, a multilevel Poisson regression model (level 1: publication, level 2: author) shows possible ways to consider fractional counting and field normalization in a statistical model (fractional counting ...Journal Article -
Incomplete recovery of cerebral blood flow dynamics in sufficiently treated high blood pressure
(2019)Journal of HypertensionObjective: Whether cerebrovascular regulation is different in patients with controlled high blood pressure (HBP) with and without small vessel disease (SVD). Methods: Sixty-seven healthy controls (mean age ± SD, 45 ± 16 years; 30 women, 37 men) and 40 patients (mean age, 64 ± 13 years; 14 women, 26 men) with HBP and different stages of SVD, underwent simultaneous recordings of the spontaneous fluctuations of BP, blood flow velocity ...Journal Article -
Visual control of steering in curve driving
(2019)Journal of VisionThis pair of studies investigated steering in the absence of continuous visual information. In a driving simulator, participants steered a curving path that was displayed either continuously or intermittently. Optic flow conditions were manipulated to alter the nature of the heading information with respect to the path being steered. Removing or biasing heading information had little effect on steering even during long and frequent path ...Journal Article -
SERPINB7 Expression Predicts Poor Pancreatic Cancer Survival Upon Gemcitabine Treatment
(2019)Translational OncologyStratification of patients with pancreatic ductal adenocarcinoma (PDAC) remains a key challenge in the field of clinical oncology. No predictive biomarkers have yet been found for any available treatment options. Previously, we identified SERPINB7 as a putative biomarker for PDAC and thus, herein, we aimed to validate our previous findings and assessed the predictive value of SERPINB7. Patients who underwent surgery and received gemcitabine ...Journal Article -
Spatiotemporally Controlled Myosin Relocalization and Internal Pressure Generate Sibling Cell Size Asymmetry
(2019)iScienceMetazoan cells can generate unequal-sized sibling cells during cell division. This form of asymmetric cell division depends on spindle geometry and Myosin distribution, but the underlying mechanics are unclear. Here, we use atomic force microscopy and live cell imaging to elucidate the biophysical forces involved in the establishment of physical asymmetry in Drosophila neural stem cells. We show that initial apical cortical expansion is ...Journal Article -
Membrane perforation by the pore-forming toxin pneumolysin
(2019)Proceedings of the National Academy of Sciences of the United States of AmericaPneumolysin (PLY), a major virulence factor of Streptococcus pneumoniae, perforates cholesterol-rich lipid membranes. PLY protomers oligomerize as rings on the membrane and then undergo a structural transition that triggers the formation of membrane pores. Structures of PLY rings in prepore and pore conformations define the beginning and end of this transition, but the detailed mechanism of pore formation remains unclear. With atomistic ...Journal Article -
Modification of Enzyme Activity by Vibrational Strong Coupling of Water
(2019)Angewandte Chemie. International EditionVibrational strong coupling (VSC) has recently emerged as a completely new tool for influencing chemical reactivity. It harnesses electromagnetic vacuum fluctuations through the creation of hybrid states of light and matter, called polaritonic states, in an optical cavity resonant to a molecular absorption band. Here, we investigate the effect of vibrational strong coupling of water on the enzymatic activity of pepsin, where a water ...Journal Article