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Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells
(2024)Cancer CellCellular senescence can exert dual effects in tumors, either suppressing or promoting tumor progression. The senescence-associated secretory phenotype (SASP), released by senescent cells, plays a crucial role in this dichotomy. Consequently, the clinical challenge lies in developing therapies that safely enhance senescence in cancer, favoring tumor-suppressive SASP factors over tumor-promoting ones. Here, we identify the retinoic-acid-receptor ...Journal Article -
Digital tools for youth health promotion: principles, policies and practices in sub-Saharan Africa
(2024)Health Promotion InternationalAlthough digital health promotion (DHP) technologies for young people are increasingly available in low- and middle-income countries (LMICs), there has been insufficient research investigating whether existing ethical and policy frameworks are adequate to address the challenges and promote the technological opportunities in these settings. In an effort to fill this gap and as part of a larger research project, in November 2022, we conducted ...Journal Article -
Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer
(2024)Cancer CellAlthough immunotherapy with PD-(L)1 blockade is routine for lung cancer, little is known about acquired resistance. Among 1,201 patients with non-small cell lung cancer (NSCLC) treated with PD-(L)1 blockade, acquired resistance is common, occurring in >60% of initial responders. Acquired resistance shows differential expression of inflammation and interferon (IFN) signaling. Relapsed tumors can be separated by upregulated or stable ...Journal Article -
A Synthesis of Global Coastal Ocean Greenhouse Gas Fluxes
(2024)Global Biogeochemical CyclesThe coastal ocean contributes to regulating atmospheric greenhouse gas concentrations by taking up carbon dioxide (CO2) and releasing nitrous oxide (N2O) and methane (CH4). In this second phase of the Regional Carbon Cycle Assessment and Processes (RECCAP2), we quantify global coastal ocean fluxes of CO2, N2O and CH4 using an ensemble of global gap-filled observation-based products and ocean biogeochemical models. The global coastal ocean ...Journal Article -
Detection and attribution of an anomaly in terrestrial photosynthesis in Europe during the COVID-19 lockdown
(2023)Science of The Total EnvironmentCarbon dioxide (CO2) uptake by plant photosynthesis, referred to as gross primary production (GPP) at the ecosystem level, is sensitive to environmental factors, including pollutant exposure, pollutant uptake, and changes in the scattering of solar shortwave irradiance (SWin) − the energy source for photosynthesis. The 2020 spring lockdown due to COVID-19 resulted in improved air quality and atmospheric transparency, providing a unique ...Journal Article -
Water circulation in Ryugu asteroid affected the distribution of nucleosynthetic isotope anomalies in returned sample
(2023)Science AdvancesStudies of material returned from Cb asteroid Ryugu have revealed considerable mineralogical and chemical heterogeneity, stemming primarily from brecciation and aqueous alteration. Isotopic anomalies could have also been affected by delivery of exogenous clasts and aqueous mobilization of soluble elements. Here, we show that isotopic anomalies for mildly soluble Cr are highly variable in Ryugu and CI chondrites, whereas those of Ti are ...Journal Article -
National records of 3000 European bee and hoverfly species: A contribution to pollinator conservation
(2023)Insect Conservation and Diversity1. Pollinators play a crucial role in ecosystems globally, ensuring the seed production of most flowering plants. They are threatened by global changes and knowledge of their distribution at the national and continental levels is needed to implement efficient conservation actions, but this knowledge is still fragmented and/or difficult to access. 2. As a step forward, we provide an updated list of around 3000 European bee and hoverfly ...Journal Article -
3D Bioprinting in Microgravity: Opportunities, Challenges, and Possible Applications in Space
(2023)Advanced Healthcare Materials3D bioprinting has developed tremendously in the last couple of years and enables the fabrication of simple, as well as complex, tissue models. The international space agencies have recognized the unique opportunities of these technologies for manufacturing cell and tissue models for basic research in space, in particular for investigating the effects of microgravity and cosmic radiation on different types of human tissues. In addition, ...Journal Article -
Role of sesquiterpenes in biogenic new particle formation
(2023)Science AdvancesBiogenic vapors form new particles in the atmosphere, affecting global climate. The contributions of monoterpenes and isoprene to new particle formation (NPF) have been extensively studied. However, sesquiterpenes have received little attention despite a potentially important role due to their high molecular weight. Via chamber experiments performed under atmospheric conditions, we report biogenic NPF resulting from the oxidation of pure ...Journal Article -
Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma
(2023)CancerBackground Anal squamous cell carcinoma (ASCC) is an infrequent tumor whose treatment has not changed since the 1970s. The aim of this study is the identification of biomarkers allowing personalized treatments and improvement of therapeutic outcomes. Methods Forty-six paraffin tumor samples from ASCC patients were analyzed by whole-exome sequencing. Copy number variants (CNVs) were identified and their relation to disease-free survival ...Journal Article