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First pre-modern record of the gyrfalcon (Falco rusticolus) in north-east Greenland
(2019)Polar ResearchGyrfalcon (Falco rusticolus) is the largest falcon in the world. It inhabits a wide range of climate zones in the Northern Hemisphere, from boreal forests in the south of its range to the arid polar deserts of the High Arctic. In Greenland, because of the harsh, remote environments in which gyrfalcons live, research related to the contemporary and pre-modern periods has been limited to the north-west, central west and central east coasts, ...Journal Article -
Representation of atmospheric blocking in the new global non-hydrostatic weather prediction model ICON
(2019)Meteorologische ZeitschriftThe correct depiction of atmospheric blocking still poses a key challenge for current numerical weather prediction (NWP) and climate models. This study evaluates the representation of blocking in the new global ICOsahedral Non-hydrostatic NWP and climate model ICON and links model mean state biases to observed blocking deviations. Blocking is identified using both an anomaly and a flow reversal approach in an eight member ensemble of ...Journal Article -
Chromatin-sensitive cryptic promoters putatively drive expression of alternative protein isoforms in yeast
(2019)Genome ResearchCryptic transcription is widespread and generates a heterogeneous group of RNA molecules of unknown function. To improve our understanding of cryptic transcription, we investigated their transcription start site (TSS) usage, chromatin organization, and posttranscriptional consequences in Saccharomyces cerevisiae. We show that TSSs of chromatin-sensitive internal cryptic transcripts retain comparable features of canonical TSSs in terms of ...Journal Article -
Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture
(2019)FEBS LettersTranscription factor (TF)‐based reprogramming of somatic tissues holds great promise for regenerative medicine. Previously, we demonstrated that the TFs GATA2, GFI1B, and FOS convert mouse and human fibroblasts to hemogenic endothelial‐like precursors that generate hematopoietic stem progenitor (HSPC)‐like cells over time. This conversion is lacking in robustness both in yield and biological function. Herein, we show that inclusion of ...Journal Article -
Direct and transgenerational effects of an experimental heatwave on early life stages in a freshwater snail
(2019)Freshwater Biology1. Global climate change imposes a serious threat to natural populations of many species. Estimates of the effects of climate change‐mediated environmental stresses are, however, often based only on their direct effects on organisms, and neglect the potential transgenerational (e.g. maternal) effects. 2. We tested whether high temperature (i.e. an experimental heatwave), which is known to reduce the performance of adult Lymnaea stagnalis ...Journal Article -
The effect of citizenship on the long-term earnings of marginalized immigrants: Quasi-experimental evidence from Switzerland
(2019)Science AdvancesWe provide evidence that citizenship catalyzes the long-term economic integration of immigrants. Despite the relevance of citizenship policy to immigrant integration, we lack a reliable understanding of the economic consequences of acquiring citizenship. To overcome nonrandom selection into naturalization, we exploit the quasi-random assignment of citizenship in Swiss municipalities that held referendums to decide the outcome of individual ...Journal Article -
Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication
(2019)Science AdvancesWe undertook a functional dissection of chromatin remodeler BAZ1B in neural crest (NC) stem cells (NCSCs) from a uniquely informative cohort of typical and atypical patients harboring 7q11.23 copy number variants. Our results reveal a key contribution of BAZ1B to NCSC in vitro induction and migration, coupled with a crucial involvement in NC-specific transcriptional circuits and distal regulation. By intersecting our experimental data ...Journal Article -
Short term exposure to fine particulate matter and hospital admission risks and costs in the Medicare population: time stratified, case crossover study
(2019)British Medical JournalJournal Article -
The School of Site: Istanbul Walkabouts
(2019)Journal of Public PedagogiesThis article focuses on the potentialities of employing the practice of walking as a critical public pedagogy in the context of the transforming territories of northern Istanbul. It will initially give background information on the current processes of neoliberal urbanization taking place in northern Istanbul. It will then, based on the experience of the independent walking project Istanbul Walkabouts, discuss how walking can be used as ...Journal Article -
Structuring Hydrogel Surfaces for Tribology
(2019)Advanced Materials InterfacesHydrogels are often used as model systems for articular cartilage due to similarities in their tribological properties. However, neither the structures nor the friction mechanisms of either system are fully understood. A key aspect of hydrogel lubrication is the nature of the polymeric structure at the surface, and the lubricating water film. A combination of neutron reflectometry and infrared spectroscopy is used to probe polymer volume ...Journal Article