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Control of a III-V MOCVD Process using Ultraviolet Absorption and Ultrasonic Concentration Monitoring
(2001)IEEE Transactions on Control Systems TechnologyMetalorganic chemical vapor deposition (MOCVD) is a key technology for the growth of compound semiconductors. This process has traditionally lacked real-time growth monitoring and control, which limits the precise reproducibility needed for high performance devices. Two complementary control approaches for the MOCVD process are investigated experimentally. The first is a feedforward disturbance rejection strategy using ultrasonic ...Journal Article -
Control of Deep Space Formation Flying Spacecraft; Relative Sensing and Switched Information
(2005)Journal of Guidance, Control, and DynamicsSpacecraft formations in deep space can be specified in terms of the relative spacecraft positions and absolute spacecraft orientations. Accurate absolute position measurements are not available and a formation control design approach, based on relative position information, is presented. This approach exploits the redundancy inherent in a relative position specification to develop a family of equivalent control topologies for optimal ...Journal Article -
Design of Distributed Decentralized Estimators for Formations with Fixed and Stochastic Communication Topologies
(2009)AutomaticaThis paper proposes a solution to the problem of synthesizing distributed decentralized estimators for a formation of agents. The collected dynamics of the formation are modeled by a discrete LTI system. In the considered estimation structure each agent of the formation carries an estimate of the entire formation state. Agents of the formation can communicate information between each other through unidirectional links modeled with a ...Journal Article -
Neural Substrates of Contextual Interference during Motor Learning Support a Model of Active Preparation
(2007)Journal of Cognitive NeuroscienceWhen individuals acquire new skills, initial performance is typically better and tasks are judged to be easier when the tasks are segregated and practiced by block, compared to when different tasks are randomly intermixed in practice. However, subsequent skill retention is better for a randomly practiced group, an effect known as contextual interference (CI). The present study examined the neural substrates of CI using functional magnetic ...Journal Article -
Transient disruption of M1 during response planning impairs subsequent offline consolidation
(2009)Experimental Brain ResearchTranscranial magnetic stimulation (TMS) was used to probe the involvement of the left primary motor cortex (M1) in the consolidation of a sequencing skill. In particular we asked: (1) if M1 is involved in consolidation of planning processes prior to response execution (2) whether movement preparation and movement execution can undergo consolidation independently and (3) whether sequence consolidation can occur in a stimulus specific manner. ...Journal Article -
Comparative genomics and disorder prediction identify biologically relevant SH3 protein interactions
(2005)PLoS Computational BiologyProtein interaction networks are an important part of the post-genomic effort to integrate a part-list view of the cell into system-level understanding. Using a set of 11 yeast genomes we show that combining comparative genomics and secondary structure information greatly increases consensus-based prediction of SH3 targets. Benchmarking of our method against positive and negative standards gave 83% accuracy with 26% coverage. The concept ...Journal Article -
Specificity and Evolvability in Eukaryotic Protein Interaction Networks
(2007)PLoS Computational BiologyProgress in uncovering the protein interaction networks of several species has led to questions of what underlying principles might govern their organization. Few studies have tried to determine the impact of protein interaction network evolution on the observed physiological differences between species. Using comparative genomics and structural information, we show here that eukaryotic species have rewired their interactomes at a fast ...Journal Article -
Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species
(2009)PLoS BiologyThe extent by which different cellular components generate phenotypic diversity is an ongoing debate in evolutionary biology that is yet to be addressed by quantitative comparative studies. We conducted an in vivo mass-spectrometry study of the phosphoproteomes of three yeast species (Saccharomyces cerevisiae, Candida albicans, and Schizosaccharomyces pombe) in order to quantify the evolutionary rate of change of phosphorylation. We ...Journal Article -
Genome-Wide Prediction of SH2 Domain Targets Using Structural Information and the FoldX Algorithm
(2008)PLoS Computational BiologyCurrent experiments likely cover only a fraction of all protein-protein interactions. Here, we developed a method to predict SH2-mediated protein-protein interactions using the structure of SH2-phosphopeptide complexes and the FoldX algorithm. We show that our approach performs similarly to experimentally derived consensus sequences and substitution matrices at predicting known in vitro and in vivo targets of SH2 domains. We use our method ...Journal Article -
Verification of the vibrational exciton approach for CO[sub 2] and N[sub 2]O nanoparticles
(2003)The Journal of Chemical PhysicsIt is investigated how far the vibrational exciton approximation is suitable to describe the characteristic band shapes in the infrared spectra of CO2 and N2O nanoparticles. The particles typically contain between 50 and 104 molecules and have spatial dimensions between 1 and 10 nm. The accuracy of the exciton approach is estimated by comparison with experimental data and quantum chemical calculations for small clusters. The spectral ...Journal Article