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Hippocampal gene expression profiling of a model of Alzheimer`s Disease upon treatment with the ACE inhibitor captopril
(2013)Extracellular senile plaques of amyloid beta (Abeta) are a pathological hallmark in brain of patients with Alzheimer`s Disease (AD). Abeta is generated by the amyloidogenic processing of the amyloid precursor protein (APP). Concomitant to Abeta load, AD brain is characterized by an increase in protein level and activity of the angiotensin-converting enzyme (ACE). ACE inhibitors are a widely used class of drugs with established benefits ...Dataset -
Microarray gene expression profiling of aortic genes of APOE-deficient mice receiving atherosclerosis treatment with the antioxidant vitamin E
(2012)Hypercholesterolemic APOE-deficient mice are a widely used experimental model of atherosclerosis and increased generation of reactive oxygen species (ROS) is a prominent feature of atherosclerosis development. To study the impact of ROS on atherogenesis, we treated APOE-deficient mice for 7 months with the antioxidant vitamin E (2000 IU/kg diet) and performed whole genome microarray gene expression profiling of aortic genes. Microarray ...Dataset -
Microarray gene expression profiling of transgenic mice with myocardium-specific over-expression of fatty acid synthase (FASN)
(2013)The fatty acid synthase (FASN) is the major fat synthesizing enzyme. FASN is an indispensable enzyme because mice with genetic deletion of Fasn are not viable. Apart from its physiological function, previous studies indicated that FASN could also exert a pathophysiological role, in the heart, because patients with heart failure showed up-reguation of FASN. To investigate the in vivo function of FASN up-regulation in the heart, we generated ...Dataset -
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Countries' Agri-Environmental Policies Database
(2024)A new database of 6124 policies at the intersection of agriculture and the environment. Implemented between 1960 and 2022 in over 200 countries. Comprises a wide range of types of policies (e.g., ranging from legislative changes to payments for ecosystem services), as well as a wide range of goals (e.g., from pesticide regulations to forest conservation). It allows to e.g. count such policies per country, filter to select specific policies, ...Dataset