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dc.contributor.author
Holland, Jenna
dc.contributor.author
Sorrell, Joyce
dc.contributor.author
Yates, Emily
dc.contributor.author
Smith, Kathleen
dc.contributor.author
Arbabi, Shahriar
dc.contributor.author
Arnold, Myrtha
dc.contributor.author
Rivir, Marita
dc.contributor.author
Morano, Rachel
dc.contributor.author
Chen, Jenny
dc.contributor.author
Zhang, Xiang
dc.contributor.author
DiMarchi, Richard
dc.contributor.author
Woods, Stephen C.
dc.contributor.author
Sanchez-Gurmaches, Joan
dc.contributor.author
Wohleb, Eric
dc.contributor.author
Perez-Tilve, Diego
dc.date.accessioned
2019-05-27T11:35:13Z
dc.date.available
2019-05-25T02:38:59Z
dc.date.available
2019-05-27T11:35:13Z
dc.date.issued
2019-05-21
dc.identifier.issn
2666-3864
dc.identifier.issn
2211-1247
dc.identifier.other
10.1016/j.celrep.2019.04.089
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/344022
dc.identifier.doi
10.3929/ethz-b-000344022
dc.description.abstract
The melanocortin system is a brain circuit that influences energy balance by regulating energy intake and expenditure. In addition, the brain-melanocortin system controls adipose tissue metabolism to optimize fuel mobilization and storage. Specifically, increased brain-melanocortin signaling or negative energy balance promotes lipid mobilization by increasing sympathetic nervous system input to adipose tissue. In contrast, calorie-independent mechanisms favoring energy storage are less understood. Here, we demonstrate that reduction of brain-melanocortin signaling actively promotes fat mass gain by activating the lipogenic program and adipocyte and endothelial cell proliferation in white fat depots independently of caloric intake via efferent nerve fibers conveyed by the common hepatic branch of the vagus nerve. Those vagally regulated obesogenic signals also contribute to the fat mass gain following chronic high-fat diet feeding. These data reveal a physiological mechanism whereby the brain controls energy stores that may contribute to increased susceptibility to obesity.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2019-05-21
ethz.journal.title
Cell Reports
ethz.journal.volume
27
en_US
ethz.journal.issue
8
en_US
ethz.journal.abbreviated
Cell Rep
ethz.pages.start
2399
en_US
ethz.pages.end
2410.e6
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-05-25T02:39:17Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-05-27T11:35:28Z
ethz.rosetta.lastUpdated
2020-02-15T19:20:24Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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