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dc.contributor.author
Sartori, Valentina
dc.contributor.author
Schumacher, Peter M.
dc.contributor.author
Bouillon, Thomas
dc.contributor.author
Luginbuehl, Martin
dc.contributor.author
Morari, Manfred
dc.date.accessioned
2020-09-10T12:36:14Z
dc.date.available
2017-06-09T11:02:50Z
dc.date.available
2020-09-10T12:36:14Z
dc.date.issued
2005
dc.identifier.isbn
0-7803-8740-6
en_US
dc.identifier.other
10.1109/IEMBS.2005.1616345
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/34906.1
dc.identifier.uri
http://hdl.handle.net/20.500.11850/34906
dc.description.abstract
A novel advisory system, the Anesthesia Advisory Display (AAD) has been recently developed. It displays information about actual and future predictions of anesthetic drug concentrations mapped to clinical end-points such as BIS, basing on the actual infusion rate combined with population pharmacokinetic and interaction pharmacodynamic (PKPD) models. According to the large variability observed among patients in clinical end-points to the same dosing history, a population model could fail in predicting the real patient's behavior: an "individualized" model is then necessary. An on-line estimation of the model's parameter for the single patients has been developed, basing on the extended Kalman filter algorithm. The method has been tested on data of 40 patients from a previous clinical study and the prediction of the individual models have been compared with the population model's.
en_US
dc.language.iso
en
en_US
dc.publisher
IEEE
en_US
dc.subject
Pharmacokinetic
en_US
dc.subject
Pharmacodynamic
en_US
dc.subject
Advisory system
en_US
dc.subject
Parameters adaptation
en_US
dc.subject
Anesthesia
en_US
dc.subject
Modeling
en_US
dc.subject
Simulation
en_US
dc.title
On-line estimation of propofol pharmacodynamic parameters
en_US
dc.type
Conference Paper
dc.date.published
2006-04-10
ethz.book.title
Proceedings of the 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference
en_US
ethz.pages.start
74
en_US
ethz.pages.end
77
en_US
ethz.event
27th Annual International Conference of the Engineering in Medicine and Biology Society (IEEE-EMBS 2005)
en_US
ethz.event.location
Shanghai, China
en_US
ethz.event.date
September 1-4, 2005
en_US
ethz.identifier.wos
ethz.identifier.nebis
005216252
ethz.publication.place
Piscataway, NJ
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich, direkt::00012 - Lehre und Forschung, direkt::00007 - Departemente, direkt::02140 - Departement Informationstechnologie und Elektrotechnik / Department of Information Technology and Electrical Engineering::02650 - Institut für Automatik (IfA) / Automatic Control Laboratory (IfA)::03416 - Morari, Manfred (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich, direkt::00012 - Lehre und Forschung, direkt::00007 - Departemente, direkt::02140 - Departement Informationstechnologie und Elektrotechnik / Department of Information Technology and Electrical Engineering::02650 - Institut für Automatik (IfA) / Automatic Control Laboratory (IfA)::03416 - Morari, Manfred (emeritus)
ethz.date.deposited
2017-06-09T11:02:59Z
ethz.source
ECIT
ethz.identifier.importid
imp59364e07b2b6418252
ethz.ecitpid
pub:56126
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2017-07-12T20:48:08Z
ethz.rosetta.lastUpdated
2021-02-15T17:08:32Z
ethz.rosetta.versionExported
true
ethz.COinS
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