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Fracture definitions in observational osteoporosis drug effects studies that leverage healthcare administrative (claims) data: a scoping review
(2022)Osteoporosis InternationalSummary Healthcare administrative (claims) data are commonly utilized to estimate drug effects. We identified considerable heterogeneity in fracture outcome definitions in a scoping review of 57 studies that estimated osteoporosis drug effects on fracture risk. Better understanding of the impact of different fracture definitions on study results is needed. Purpose Healthcare administrative (claims) data are frequently used to estimate ...Review Article -
Phenotypic flux: The role of physiology in explaining the conundrum of bacterial persistence amid phage attack
(2022)Virus EvolutionBacteriophages, the viruses of bacteria, have been studied for over a century. They were not only instrumental in laying the foundations of molecular biology, but they are also likely to play crucial roles in shaping our biosphere and may offer a solution to the control of drug-resistant bacterial infections. However, it remains challenging to predict the conditions for bacterial eradication by phage predation, sometimes even under ...Review Article -
Peripheral neurostimulation for encoding artificial somatosensations
(2022)European Journal of NeuroscienceThe direct neural stimulation of peripheral or central nervous systems has been shown as an effective tool to treat neurological conditions. The electrical activation of the nervous sensory pathway can be adopted to restore the artificial sense of touch and proprioception in people suffering from sensory-motor disorders. The modulation of the neural stimulation parameters has a direct effect on the electrically induced sensations, both ...Review Article -
Iron-Catalyzed Olefin Metathesis: Recent Theoretical and Experimental Advances
(2022)Chemistry - A European JournalThe "metathesis reaction" is a straightforward and often metal-catalyzed chemical reaction that transforms two hydrocarbon molecules to two new hydrocarbons by exchange of molecular fragments. Alkane, alkene and alkyne metathesis have become an important tool in synthetic chemistry and have provided access to complex organic structures. Since the discovery of industrial olefin metathesis in the 1960s, many modifications have been reported; ...Review Article -
Review of Particle Physics
(2022)Progress of Theoretical and Experimental PhysicsThe Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 2,143 new measurements from 709 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search ...Review Article -
Priors in Bayesian Deep Learning: A Review
(2022)International Statistical ReviewWhile the choice of prior is one of the most critical parts of the Bayesian inference workflow, recent Bayesian deep learning models have often fallen back on vague priors, such as standard Gaussians. In this review, we highlight the importance of prior choices for Bayesian deep learning and present an overview of different priors that have been proposed for (deep) Gaussian processes, variational autoencoders and Bayesian neural networks. ...Review Article -
The gate to metastasis: key players in cancer cell intravasation
(2022)The FEBS JournalMetastasis is a leading cause of cancer-related death and consists of a sequence of events including tumor expansion, intravasation of cancer cells into the circulation, survival in the bloodstream, extravasation at distant sites, and subsequent organ colonization. Particularly, intravasation is a process whereby cancer cells transverse the endothelium and leave the primary tumor site, pioneering the metastatic cascade. The identification ...Review Article -
Digital innovations for sustainable and resilient agricultural systems
(2023)European Review of Agricultural EconomicsDigitalisation is rapidly transforming the agri-food sector. This paper investigates emerging opportunities, challenges and policy options. We show that digital innovations can contribute to more sustainable and resilient agricultural systems. For example, digital innovations enable increased productivity, reduced environmental footprints and higher resilience of farms. However, these optimistic outcomes of increasing digitalisation of ...Review Article -
Epidemiological inference from pathogen genomes: A review of phylodynamic models and applications
(2022)Virus EvolutionPhylodynamics requires an interdisciplinary understanding of phylogenetics, epidemiology, and statistical inference. It has also experienced more intense application than ever before amid the SARS-CoV-2 pandemic. In light of this, we present a review of phylodynamic models beginning with foundational models and assumptions. Our target audience is public health researchers, epidemiologists, and biologists seeking a working knowledge of the ...Review Article -
Temperature-Controlled Electrospray Ionization: Recent Progress and Applications
(2021)Chemistry - A European JournalNative electrospray ionization (ESI) and nanoelectrospray ionization (nESI) allow researchers to analyze intact biomolecules and their complexes by mass spectrometry (MS). The data acquired using these soft ionization techniques provide a snapshot of a given biomolecules structure in solution. Over the last thirty years, several nESI and ESI sources capable of controlling spray solution temperature have been developed. These sources can ...Review Article