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Bone fragility in diabetes: novel concepts and clinical implications
(2022)The Lancet Diabetes & EndocrinologyIncreased fracture risk represents an emerging and severe complication of diabetes. The resulting prolonged immobility and hospitalisations can lead to substantial morbidity and mortality. In type 1 diabetes, bone mass and bone strength are reduced, resulting in up to a five-times greater risk of fractures throughout life. In type 2 diabetes, fracture risk is increased despite a normal bone mass. Conventional dual-energy x-ray absorptiometry ...Review Article -
3d bioprinting of human tissues: Biofabrication, bioinks and bioreactors
(2021)International Journal of Molecular SciencesThe field of tissue engineering has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes for regenerative medicine and pharmaceutical research. Conventional scaffold‐based approaches are limited in their capacity to produce constructs with the functionality and complexity of native tissue. Three‐dimensional (3D) bioprinting offers exciting prospects for scaffolds fabrication, as it ...Review Article -
Bone remodeling and mechanobiology around implants: Insights from small animal imaging
(2018)Journal of Orthopaedic ResearchReview Article -
The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community
(2020)Journal of Bone and Mineral ResearchThe development of high-throughput genotyping technologies and large biobank collections, complemented with rapid methodological advances in statistical genetics, has enabled hypothesis-free genome-wide association studies (GWAS), which have identified hundreds of genetic variants across many loci associated with musculoskeletal conditions. Similarly, basic scientists have valuable molecular cellular and animal data based on musculoskeletal ...Review Article -
Clinical Data for Parametrization of In Silico Bone Models Incorporating Cell-Cytokine Dynamics: A Systematic Review of Literature
(2022)Frontiers in Bioengineering and BiotechnologyIn silico simulations aim to provide fast, inexpensive, and ethical alternatives to years of costly experimentation on animals and humans for studying bone remodeling, its deregulation during osteoporosis and the effect of therapeutics. Within the varied spectrum of in silico modeling techniques, bone cell population dynamics and agent-based multiphysics simulations have recently emerged as useful tools to simulate the effect of specific ...Review Article -
Magnetic resonance angiography: methods and its applications to the coronary arteries
(1994)Technology and Health CareThe non-invasive visualisation of the coronary arteries with magnetic resonance imaging would be a highly useful tool for the diagnosis of coronary artery disease, with a potential to partly replace current invasive imaging modalities, and would be a step towards more patient comfort. While magnetic resonance (MR) angiography of most larger blood vessels can nowadays be performed routinely, current techniques are inadequate to image the ...Review Article -
Longitudinal imaging of the ageing mouse
(2016)Mechanisms of Ageing and DevelopmentSeveral non-invasive imaging techniques are used to investigate the effect of pathologies and treatments over time in mouse models. Each preclinical in vivo technique provides longitudinal and quantitative measurements of changes in tissues and organs, which are fundamental for the evaluation of alterations in phenotype due to pathologies, interventions and treatments. However, it is still unclear how these imaging modalities can be used ...Review Article -
Computational modelling of bone augmentation in the spine
(2015)Journal of Orthopaedic TranslationReview Article -
Towards quantitative 3D imaging of the osteocyte lacuno-canalicular network
(2010)BoneReview Article -
The evolution of simulation techniques for dynamic bone tissue engineering in bioreactors
(2015)Journal of Tissue Engineering and Regenerative MedicineBone tissue engineering aims to overcome the drawbacks of current bone regeneration techniques in orthopaedics. Bioreactors are widely used in the field of bone tissue engineering, as they help support efficient nutrition of cultured cells with the possible combination of applying mechanical stimuli. Beneficial influencing parameters of in vitro cultures are difficult to find and are mostly determined by trial and error, which is associated ...Review Article