A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with 68Ga, 44Sc, 177Lu and 161Tb
dc.contributor.author
Talip, Zeynep
dc.contributor.author
Favaretto, Chiara
dc.contributor.author
Geistlich, Susanne
dc.contributor.author
van der Meulen, Nicholas P.
dc.date.accessioned
2020-03-05T12:59:17Z
dc.date.available
2020-03-05T03:17:25Z
dc.date.available
2020-03-05T12:59:17Z
dc.date.issued
2020-02
dc.identifier.issn
1420-3049
dc.identifier.other
10.3390/molecules25040966
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/403138
dc.identifier.doi
10.3929/ethz-b-000403138
dc.description.abstract
The production of novel radionuclides is the first step towards the development of new effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and clinical phases. In this review, novel radiometal production for medical applications is briefly elucidated. The production status of the imaging nuclide 44Sc and the therapeutic β--emitter nuclide 161Tb are compared to their more established counterparts, 68Ga and 177Lu according to their targetry, irradiation process, radiochemistry, and quality control aspects. The detailed discussion of these significant issues will help towards the future introduction of these promising radionuclides into drug manufacture for clinical application under Good Manufacturing Practice (GMP).
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
cyclotron
en_US
dc.subject
reactor
en_US
dc.subject
novel radionuclides
en_US
dc.subject
radiopharmaceuticals
en_US
dc.subject
imaging
en_US
dc.subject
therapy
en_US
dc.subject
theranostics
en_US
dc.subject
scandium-44
en_US
dc.subject
terbium-161
en_US
dc.subject
gallium-68
en_US
dc.subject
lutetium-177
en_US
dc.subject
Good Manufacturing Practice
en_US
dc.title
A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with 68Ga, 44Sc, 177Lu and 161Tb
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-02-20
ethz.journal.title
Molecules
ethz.journal.volume
25
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
Molecules
ethz.pages.start
966
en_US
ethz.size
29 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
ethz.date.deposited
2020-03-05T03:17:31Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-03-05T12:59:27Z
ethz.rosetta.lastUpdated
2024-02-02T10:31:42Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=A%20Step-by-Step%20Guide%20for%20the%20Novel%20Radiometal%20Production%20for%20Medical%20Applications:%20Case%20Studies%20with%2068Ga,%2044Sc,%20177Lu%20and%20161Tb&rft.jtitle=Molecules&rft.date=2020-02&rft.volume=25&rft.issue=4&rft.spage=966&rft.issn=1420-3049&rft.au=Talip,%20Zeynep&Favaretto,%20Chiara&Geistlich,%20Susanne&van%20der%20Meulen,%20Nicholas%20P.&rft.genre=article&rft_id=info:doi/10.3390/molecules25040966&
Files in this item
Publication type
-
Review Article [3931]