Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C–H Amination
dc.contributor.author
Falk, Eric
dc.contributor.author
Gasser, Valentina C.M.
dc.contributor.author
Morandi, Bill
dc.date.accessioned
2022-02-07T14:05:03Z
dc.date.available
2021-02-09T15:35:34Z
dc.date.available
2021-02-12T15:01:34Z
dc.date.available
2021-03-25T15:07:46Z
dc.date.available
2021-03-25T15:08:30Z
dc.date.available
2021-06-08T12:42:16Z
dc.date.available
2021-06-09T04:58:22Z
dc.date.available
2022-02-07T14:05:03Z
dc.date.issued
2021-02-19
dc.identifier.issn
1523-7060
dc.identifier.issn
1523-7052
dc.identifier.other
10.1021/acs.orglett.1c00099
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/468727
dc.identifier.doi
10.3929/ethz-b-000468727
dc.description.abstract
We report both an intermolecular C–H amination of arenes to access N-methylanilines and an intramolecular variant for the synthesis of tetrahydroquinolines. A newly developed, highly electrophilic aminating reagent was key for the direct synthesis of unprotected N-methylanilines from simple arenes. The reactions display a broad functional group tolerance and employ catalytic amounts of a benign iron salt under mild reaction conditions.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
American Chemical Society
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.title
Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C–H Amination
en_US
dc.type
Journal Article
dc.rights.license
In Copyright - Non-Commercial Use Permitted
dc.date.published
2021-02-05
ethz.journal.title
Organic Letters
ethz.journal.volume
23
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
Org. Lett.
ethz.pages.start
1422
en_US
ethz.pages.end
1426
en_US
ethz.size
6 p. accepted version
en_US
ethz.version.deposit
acceptedVersion
en_US
ethz.grant
Catalytic synthesis of unprotected amines and heterocycles
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::09634 - Morandi, Bill / Morandi, Bill
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::09634 - Morandi, Bill / Morandi, Bill
en_US
ethz.grant.agreementno
184658
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projekte MINT
ethz.date.deposited
2021-02-09T15:35:44Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.date.embargoend
2022-02-04
ethz.rosetta.installDate
2021-03-25T15:08:38Z
ethz.rosetta.lastUpdated
2022-03-29T18:40:35Z
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true
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