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dc.contributor.author
Kröpfl, Julia M.A.
dc.contributor.author
Beltrami, Fernando G.
dc.contributor.author
Rehm, Markus
dc.contributor.author
Gruber, Hans-Jürgen
dc.contributor.author
Stelzer, Ingeborg
dc.contributor.author
Spengler, Christina M.
dc.date.accessioned
2021-05-31T14:45:27Z
dc.date.available
2021-03-05T06:43:10Z
dc.date.available
2021-03-05T06:45:38Z
dc.date.available
2021-05-31T14:45:27Z
dc.date.issued
2021-07
dc.identifier.issn
1440-2440
dc.identifier.other
10.1016/j.jsams.2021.01.010
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/473116
dc.identifier.doi
10.3929/ethz-b-000473116
dc.description.abstract
Objectives Regular physical exercise is known to protect endothelial integrity. It has been proposed that acute exercise-induced changes of the (anti-)oxidative system influence early (glycocalyx shedding) and sustained endothelial activation (shedding of endothelial cells, ECs) as well as endothelial-cell repair by circulating hematopoietic stem and progenitor cells (HPCs). However, results are not conclusive and data in trained participants performing different exercise modalities is lacking. Design Eighteen healthy, well-trained participants (9 runners, 9 cyclists; age: 29.7 ± 4.2 yrs) performed a strenuous acute exercise session consisting of 4 bouts of 4-min high-intensity with decreasing power profile and 3-min low-intensity in-between. Methods Average power/speed of intense phases was 85% of the peak achieved in a previous incremental test. Before and shortly after exercise, total oxidative and antioxidative capacities (TAC), shedding of syndecan-1, heparan sulfate, hyaluronan, ECs, and circulating HPCs were investigated. Results TAC decreased from 1.81 ± 0.42 nmol/L to 1.47 ± 0.23 nmol/L post-exercise (p = 0.010) only in runners. Exercise-induced early and sustained endothelial activation were enhanced post-exercise- syndecan-1: 103.2 ± 63.3 ng/mL to 111.3 ± 71.3 ng/mL, heparan sulfate: from 2637.9 ± 800.1 ng/mL to 3197.1 ± 1416.3 ng/mL, both p < 0.05; hyaluronan: 84.3 ± 21.8 ng/mL to 121.4 ± 29.4 ng/mL, ECs: from 6.6 ± 4.5 cells/μL to 9.5 ± 6.2 cells/μL, both p < 0.01; results were not different between exercise modalities and negatively related to TAC concentrations post-exercise. HPC proportions and self-renewal ability were negatively, while EC concentrations were positively associated with circulating hyaluronan concentrations. Conclusions These results highlight the importance of the antioxidative system to prevent the endothelium from acute exercise-induced vascular injury – independent of exercise modality – in well-trained participants. Endothelial-cell repair is associated with hyluronan signaling, possibly a similar mechanism as in wound repair.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
High-intensity interval training
en_US
dc.subject
Glycocalyx
en_US
dc.subject
Vascular endothelial cells
en_US
dc.subject
Hematopoietic stem cells
en_US
dc.subject
Oxygen radical absorbance capacity
en_US
dc.title
Acute exercise-induced glycocalyx shedding does not differ between exercise modalities, but is associated with total antioxidative capacity
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2021-02-06
ethz.journal.title
Journal of Science and Medicine in Sport
ethz.journal.volume
24
en_US
ethz.journal.issue
7
en_US
ethz.pages.start
689
en_US
ethz.pages.end
695
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::08691 - Spengler, Christina (Tit.-Prof.)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::08691 - Spengler, Christina (Tit.-Prof.)
ethz.date.deposited
2021-03-05T06:43:24Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2021-05-31T14:45:37Z
ethz.rosetta.lastUpdated
2021-05-31T14:45:37Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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