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Author
Date
2021Type
- Book Chapter
Abstract
Branching morphogenesis generates epithelial trees which facilitate gas exchange, filtering, as well as secretion processes with their large surface to volume ratio. In this review, we focus on the developmental mechanisms that control the early stages of lung branching morphogenesis. Lung branching morphogenesis involves the stereotypic, recurrent definition of new branch points, subsequent epithelial budding, and lung tube elongation. We discuss current models and experimental evidence for each of these steps. Finally, we discuss the role of the mesenchyme in determining the organ-specific shape. Show more
Publication status
publishedEditor
Book title
Cellular Networks in DevelopmentJournal / series
Current Topics in Developmental BiologyVolume
Pages / Article No.
Publisher
Academic PressSubject
Lung branching morphogenesis; Ligand-receptor based Turing mechanism; Epithelial tube; Directional growth; Computational model; Shear stress; Cell-based tissue simulationsOrganisational unit
03791 - Iber, Dagmar / Iber, Dagmar
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Is new version of: http://hdl.handle.net/20.500.11850/460510
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