Open access
Date
2021-09-17Type
- Journal Article
Abstract
A nickel-catalyzed cyanation of aryl thioethers using Zn(CN)2 as a cyanide source has been developed to access functionalized aryl nitriles. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) in combination with the base KOAc (potassium acetate) is essential for achieving this transformation efficiently. This reaction involves both a C–S bond activation and a C–C bond formation. The scalability, low catalyst and reagents loadings, and high functional group tolerance have enabled both late-stage derivatization and polymer recycling, demonstrating the reaction’s utility across organic chemistry. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000508239Publication status
publishedExternal links
Journal / series
Organic LettersVolume
Pages / Article No.
Publisher
American Chemical SocietyOrganisational unit
09634 - Morandi, Bill / Morandi, Bill
Funding
184658 - Catalytic synthesis of unprotected amines and heterocycles (SNF)
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