Open access
Date
2021-12Type
- Review Article
Abstract
Bacteria constantly monitor their environment to adapt their inner makeup. Beyond providing chemical sustenance, metabolism provides most of the feedback on the cellular environment via metabolite binding to regulatory proteins or mRNA. Although first metabolite-protein interactions were discovered more than 60 years ago, identification of new interactions is still technically challenging and time-consuming. Here, we compiled and quantified the current knowledge on metabolite-protein interactions and review recent advances in the identification of interactions and in understanding how metabolites act as signals to transcription factors, two-component systems, protein kinases, and riboswitches. New systematic methods of metabolite-protein identification and omics integration will accelerate the pace of discovery, a remaining challenge is understanding of functionality and the coordination of local and global metabolic signals across different regulatory layers. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000517650Publication status
publishedExternal links
Journal / series
Current Opinion in Systems BiologyVolume
Pages / Article No.
Publisher
ElsevierSubject
Regulation; Metabolism; Transcription factors; Kinases; SignalingOrganisational unit
03713 - Sauer, Uwe / Sauer, Uwe
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