Open access
Date
2022-03-03Type
- Journal Article
Abstract
Morphogen gradients encode positional information during development. How high patterning precision is achieved despite natural variation in both the morphogen gradients and in the readout process, is still largely elusive. Here, we show that the positional error of gradients in the mouse neural tube has previously been overestimated, and that the reported accuracy of the central progenitor domain boundaries in the mouse neural tube can be achieved with a single gradient, rather than requiring the simultaneous readout of opposing gradients. Consistently and independently, numerical simulations based on measured molecular noise levels likewise result in lower gradient variabilities than reported. Finally, we show that the patterning mechanism yields progenitor cell numbers with even greater precision than boundary positions, as gradient amplitude changes do not affect interior progenitor domain sizes. We conclude that single gradients can yield the observed developmental precision, which provides prospects for tissue engineering. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000535149Publication status
publishedExternal links
Journal / series
Nature CommunicationsVolume
Pages / Article No.
Publisher
NatureOrganisational unit
03791 - Iber, Dagmar / Iber, Dagmar
Funding
170930 - A 3D Cell-Based Simulation Framework for Morphogenetic Problems (SNF)
Related publications and datasets
Is new version of: http://hdl.handle.net/20.500.11850/526495
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