Advantages of nanoscale bioactive glass as inorganic filler in alginate hydrogels for drug delivery and biofabrication
Open access
Date
2022Type
- Journal Article
ETH Bibliography
yes
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Abstract
Sodium alginate is a natural biocompatible polymer obtained from brown algae which has found numerous biomedical applications. Inorganic fillers, such as nanosized bioactive glass (nBG) particles, are well known for their outstanding properties in terms of being osteoconductive and osteoinductive and therefore finding application in bone tissue engineering. In this study, the impact of nBG particles on alginate hydrogels was investigated for applications of the composite hydrogel in biofabrication and drug delivery. The influence of nBG particles on properties such as printability, drug release ability and bioactivity (capability to form a hydroxyapatite (HAp) layer on the surface of nBG-alginate capsules) was studied. In vitro cell studies proved high cell viability of all inks. Due to the presence of nBG particles, more precise printed grids and pore sizes were achieved. Moreover, a decrease of the release of the model drug icariin in the presence of nBG particles was determined. The formation of a HAp layer on the surface of nBG-alginate capsules was assessed by FTIR, XRD and SEM. Overall, the addition of nBG particles into alginate hydrogels led to the improvement of the relevant properties investigated. Therefore, nBG-alginate systems should gain more attention for 3 D bioprinting and drug delivery approaches. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000537778Publication status
publishedExternal links
Journal / series
European Journal of MaterialsVolume
Pages / Article No.
Publisher
Taylor & FrancisSubject
Bioactive glass; Drug release; 3D printing; Alginate; Tissue engineering; BiofabricationOrganisational unit
03673 - Stark, Wendelin J. / Stark, Wendelin J.
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ETH Bibliography
yes
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