Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age
Abstract
Introduction: Hippocampal atrophy is an established Alzheimer’s Disease (AD) biomarker. Volume loss in specific subregions as measurable with ultra-high field magnetic resonance imaging (MRI) may reflect earliest pathological alterations.
Methods: Data from positron emission tomography (PET) for estimation of cortical amyloid β (Aβ) and high-resolution 7 Tesla T1 MRI for assessment of hippocampal subfield volumes were analyzed in 61 non-demented elderly individuals who were divided into risk-categories as defined by high levels of cortical Aβ and low performance in standardized episodic memory tasks.
Results: High cortical Aβ and low episodic memory interactively predicted subicular volume [F(3,57) = 5.90, p = 0.018]. The combination of high cortical Aβ and low episodic memory was associated with significantly lower subicular volumes, when compared to participants with high episodic memory (p = 0.004).
Discussion: Our results suggest that low subicular volume is linked to established indicators of AD risk, such as increased cortical Aβ and low episodic memory. Our data support subicular volume as a marker of dementia-risk susceptibility in old-aged non-demented persons. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000540012Publication status
publishedExternal links
Journal / series
Frontiers in Aging NeuroscienceVolume
Pages / Article No.
Publisher
Frontiers MediaSubject
ultra-high field MRI; 7 Tesla; hippocampus subfield segmentation; prodromal AD; episodic memory; iron; subiculum; Alzheimer's diseaseOrganisational unit
03628 - Prüssmann, Klaas P. / Prüssmann, Klaas P.
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