Electrogenetics: Bridging synthetic biology and electronics to remotely control the behavior of mammalian designer cells
Open access
Date
2022-06Type
- Review Article
Abstract
Electrogenetics, the combination of electronics and genetics, is an emerging field of mammalian synthetic biology in which electrostimulation is used to remotely program user-designed genetic elements within designer cells to generate desired outputs. Here, we describe recent advances in electro-induced therapeutic gene expression and therapeutic protein secretion in engineered mammalian cells. We also review available tools and strategies to engineer electro-sensitive therapeutic designer cells that are able to sense electrical pulses and produce appropriate clinically relevant outputs in response. We highlight current limitations facing mammalian electrogenetics and suggest potential future directions for research. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000547194Publication status
publishedExternal links
Journal / series
Current Opinion in Chemical BiologyVolume
Pages / Article No.
Publisher
ElsevierSubject
Synthetic biology; Therapeutic cell engineering; Traceless switch control; Electrostimulation; ElectrogeneticsOrganisational unit
03694 - Fussenegger, Martin / Fussenegger, Martin
Funding
785800 - Electrogenetics - Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression (EC)
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