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dc.contributor.author
Avilla Royo, Eva
dc.contributor.author
Ochsenbein-Kölble, Nicole
dc.contributor.author
Vonzun, Ladina
dc.contributor.author
Ehrbar, Martin
dc.date.accessioned
2022-06-24T12:26:23Z
dc.date.available
2022-06-23T02:56:00Z
dc.date.available
2022-06-24T12:26:23Z
dc.date.issued
2022
dc.identifier.issn
2047-4830
dc.identifier.issn
2047-4849
dc.identifier.other
10.1039/d2bm00401a
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/554165
dc.description.abstract
Minimally invasive interventions to ameliorate or correct fetal abnormalities are becoming a clinical reality. However, the iatrogenic preterm prelabor rupture of the fetal membranes (FMs) (iPPROM), which may result in preterm birth, remains a main complication. Despite the cause of iPPROM not being fully known, the puncture created by the fetoscope remains unhealed until the end of the pregnancy, which permits chorioamniotic separation and amniotic fluid leakage. Hence, there is an urgent need to develop strategies to treat the FMs after minimally invasive interventions. However, none of the previously tested strategies has been clinically translated. Here, we review the current knowledge about the FMs starting from their development and present the different models that have been developed both in vitro and ex vivo. We also systematically review and summarize the different approaches that have been investigated to plug, seal, heal or suture the FMs both in preclinical and clinical studies and discuss their limitations, outcomes, and future directions.
en_US
dc.language.iso
en
en_US
dc.publisher
Royal Society of Chemistry
en_US
dc.title
Biomaterial-based treatments for the prevention of preterm birth after iatrogenic rupture of the fetal membranes
en_US
dc.type
Review Article
dc.date.published
2022-04-25
ethz.journal.title
Biomaterials Science
ethz.journal.abbreviated
Biomater Sci
ethz.size
21 p.
en_US
ethz.identifier.wos
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology
en_US
ethz.date.deposited
2022-06-23T02:56:18Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.exportRequired
true
ethz.COinS
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