A high-density CMOS multi-modality joint sensor/stimulator array with 1024 pixels for holistic real-time cellular characterization
Abstract
This paper presents a fully integrated 1024-pixel world-first joint multi-modality sensor/stimulator array in CMOS for holistic real-time cell characterization. Each pixel supports extracellular voltage recording, optical detection, and cellular impedance measurement, as well as current-mode cellular stimulation. Four independent on-chip temperature sensors monitor the ambient temperature variation. The chip is implemented in a 130nm CMOS process with a pixel size of 58µm×58µm, achieving the largest array-size and smallest pixel for a multi-modality joint sensor/stimulator array in CMOS. The electrical and biological measurements demonstrate the utility of this high-density multi-modality array in cell-based assays for drug and chemical screening. Show more
Publication status
publishedExternal links
Book title
2016 IEEE Symposium on VLSI Circuits (VLSI-Circuits)Pages / Article No.
Publisher
CurranEvent
Organisational unit
09757 - Wang, Hua / Wang, Hua
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