A Phthalocyanine with an Olefin at Its Center as PotentialG-Quadruplex Ligand
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Date
2022-11-18Type
- Journal Article
ETH Bibliography
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Abstract
We report the synthesis of a polycyclic dicationic phthalocyanine through N-functionalization of the internal core with an olefin (C=C) and compared with its porphyrin analogues. Potential application of this new class of molecules as G-quadruplex (G4)-targeting ligand has been investigated by computational point of view, showing encouraging results with respect to the current benchmarks. Show more
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publishedExternal links
Journal / series
ChemistrySelectVolume
Pages / Article No.
Publisher
Wiley-VCHSubject
Phthalocyanines; Extended π-conjugation; G-Quadruplex-targeting ligands; Polycyclic Hydrocarbons; Density Functional CalculationsFunding
183660 - Porphyrin-based imaging probe for the detection of oncogene promoter quadruplex DNA (SNF)
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ETH Bibliography
yes
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