Mass-Spec, Cryo-EM and AI join forces for a close look at the transporter complex in cilia
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Date
2023-01-16Type
- Journal Article
ETH Bibliography
yes
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Abstract
The intraflagellar transport (IFT) complex transports components between the cytoplasm and the ciliary tip. Two studies now report on the atomic structure of IFT-B, the core of IFT, using cutting-edge technology, such as cross-linking mass spectrometry (MS), cryo-electron tomography (cryo-ET) and Alphafold2-enabled AI-based folding prediction. The 3D structure of IFT-B reveals how the 15 component proteins are arranged to stabilize this gigantic complex and suggests a dynamic interplay between the proteins. Show more
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publishedExternal links
Journal / series
The EMBO JournalVolume
Pages / Article No.
Publisher
EMBO PressFunding
192646 - Exploring protein dynamics with atomic resolution (SNF)
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ETH Bibliography
yes
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