RGD Cyclopeptide Equipped with a Lysine-Engaging Salicylaldehyde Showing Enhanced Integrin Affinity and Cell Detachment Potency
Abstract
Salicylaldehyde (SA) derivatives are emerging as useful fragments to obtain reversible-covalent inhibitors interacting with the lysine residues of the target protein. Here the SA installation at the C terminus of an integrin-binding cyclopeptide, leading to enhanced ligand affinity for the receptor as well as stronger biological activity in cultured glioblastoma cells is reported. Show more
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https://doi.org/10.3929/ethz-b-000604148Publication status
publishedExternal links
Journal / series
Chemistry - A European JournalVolume
Pages / Article No.
Publisher
Wiley-VCHSubject
aldehydes; cell adhesion; covalent inhibitors; integrins; peptidomimeticsMore
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