An emerging class of nucleic acid-sensing regulators in bacteria: WYL domain-containing proteins
Open access
Date
2023-08Type
- Journal Article
Abstract
Transcriptional regulation plays a central role in adaptation to changing environments for all living organisms. Recently, proteins belonging to a novel widespread class of bacterial transcription factors have been characterized in mycobacteria and Proteobacteria. Those multidomain proteins carry a WYL domain that is almost exclusive to the domain of bacteria. WYL domain-containing proteins act as regulators in different cellular contexts, including the DNA damage response and bacterial immunity. WYL domains have an Sm-like fold with five antiparallel β-strands arranged into a β-sandwich preceded by an α-helix. A common feature of WYL domains is their ability to bind nucleic acids that regulate their activity. In this review, we discuss recent progress made toward the understanding of WYL domain-containing proteins as transcriptional regulators, their structural features, and molecular mechanisms, as well as their functional roles in bacterial physiology. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000607329Publication status
publishedExternal links
Journal / series
Current Opinion in MicrobiologyVolume
Pages / Article No.
Publisher
ElsevierOrganisational unit
08811 - Weber-Ban, Eilika (Tit.-Prof.)
Funding
185250 - In vivo Roles and Molecular Mechanism of the Mycobacterial Pup-proteasome System (SNF)
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