Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility
Abstract
Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen, leading to the accumulation of advanced glycation end-products (AGEs) cross-links in collagenous tissues. More recently, AGEs content has been related to loss of bone quality, independent of bone mass, and increased fracture risk with aging and diabetes. Loss of bone quality is mostly attributed to changes in material properties, structural organization, or cellular remodeling. Though all these factors play a role in bone fragility disease, some common recurring patterns can be found between diabetic and age-related bone fragility. The main pattern we will discuss in this viewpoint is the increase of fibrillar collagen stiffness and loss of collagen-induced plasticity with AGE accumulation. This study focused on recent related experimental studies and discusses the correlation between fluorescent AGEs content at the molecular and fibrillar scales, collagen deformation mechanisms at the nanoscale, and resistance to bone fracture at the macroscale. Show more
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https://doi.org/10.3929/ethz-b-000619248Publication status
publishedExternal links
Journal / series
BiocellVolume
Pages / Article No.
Publisher
Tech Science PressSubject
Bone fragility; Advanced glycation end-products; Collagen; Diabetes; AgingOrganisational unit
09650 - Kammer, David / Kammer, David
09650 - Kammer, David / Kammer, David
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