Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?
Abstract
The bacterial stringent response and its effector alarmone guano -sine penta-or tetra - phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (virulence). (p)ppGpp does so by binding to its numerous target pro-teins and reprograming bacterial transcriptome to tune down the synthesis of nucleotides and rRNA/tRNA, and up-regulate amino acid biosynthesis genes. Recent identification of more novel (p)ppGpp direct binding proteins in Esche-richia coli and their deep studies have unveiled unprecedented details of how (p)ppGpp coordinates the nucleotide and amino acid metabolic pathways upon stringent response; however, the mechanistic link between nucleotide and amino acid metabolisms remains still incompletely understood. Here we propose the metabolite ribose 5'-phosphate as the key link between nucleo-tide and amino acid metabolisms and a working model integrating both the transcriptional and metabolic effects of (p)ppGpp on E. coli physiological ad-aptation during the stringent response. Show more
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https://doi.org/10.3929/ethz-b-000623495Publication status
publishedExternal links
Journal / series
Microbial CellVolume
Pages / Article No.
Publisher
Shared Science PublishersSubject
(p)ppGpp; stringent response; nucleotide; amino acid; ribose 5'-phosphateOrganisational unit
03713 - Sauer, Uwe / Sauer, Uwe
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