Integrative modeling of hemodynamic changes and perfusion impairment in coronary microvascular disease
Open access
Date
2023-07-26Type
- Journal Article
ETH Bibliography
yes
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Abstract
Introduction: Coronary microvascular disease is one of the responsible factors for cardiac perfusion impairment. Due to diagnostic and treatment challenges, this pathology (characterized by alterations to microvasculature local hemodynamics) represents a significant yet unsolved clinical problem.Methods: Due to the poor understanding of the onset and progression of this disease, we propose a new and noninvasive strategy to quantify in-vivo hemodynamic changes occurring in the microvasculature. Specifically, we here present a conceptual workflow that combines both in-vitro and in-silico modelling for the analysis of the hemodynamic alterations in the microvasculature.Results: First, we demonstrate a hybrid additive manufacturing process to fabricate circular cross-section, biocompatible fluidic networks in polytetrafluoroethylene. We then use these microfluidic devices and computational fluid dynamics to simulate different degrees of perfusion impairment.Discussion: Ultimately, we show that the developed workflow defines a robust platform for the multiscale analysis of multifactorial events occurring in coronary microvascular disease. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000627322Publication status
publishedExternal links
Journal / series
Frontiers in Bioengineering and BiotechnologyVolume
Pages / Article No.
Publisher
Frontiers MediaSubject
3D printing; CFD analysis; WSS; fabrication; local hemodynamics; nonobstructive coronary artery diseaseOrganisational unit
03914 - deMello, Andrew / deMello, Andrew
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ETH Bibliography
yes
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