Non-invasive temporal interference electrical stimulation of the human hippocampus
Abstract
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging and behavioral experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000640045Publication status
publishedExternal links
Journal / series
Nature NeuroscienceVolume
Pages / Article No.
Publisher
NatureSubject
Biological techniques; Medical research; NeuroscienceRelated publications and datasets
Is referenced by: https://doi.org/10.1038/s41593-023-01517-y
Notes
A Publisher Correction to this article was published on 13 November 2023 and this article has been updated.More
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