Proteomic and functional genetic landscapes underlying T cell biology in ageing, autoimmunity & cancer
Embargoed until 2026-12-06
Author
Date
2023Type
- Doctoral Thesis
ETH Bibliography
yes
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Abstract
Tightly regulated immune responses are required to recognize and eliminate pathogenic threats while mitigating collateral damage to host-tissues. In mammals, CD4+ and CD8+ T cells play a pivotal role in orchestrating and executing these functions, respectively. Maintaining effective T cell programs over the lifespan of an individual is therefore essential for protection against disease. Using a combination of mass-spectrometry based proteomics and functional genetic screens, we investigated the mechanisms governing effective T cell responses in the contexts of ageing, auto-immunity, and cancer. Show more
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https://doi.org/10.3929/ethz-b-000645505Publication status
publishedExternal links
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Publisher
ETH ZurichSubject
immunology; Cancer; Ageing; CRISPR screen; Treg; ProteomicsOrganisational unit
09635 - Corn, Jacob / Corn, Jacob
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ETH Bibliography
yes
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