Mouse models of accelerated aging in musculoskeletal research for assessing frailty, sarcopenia, and osteoporosis – A review
Open access
Date
2024-01Type
- Review Article
ETH Bibliography
yes
Altmetrics
Abstract
Musculoskeletal aging encompasses the decline in bone and muscle function, leading to conditions such as frailty, osteoporosis, and sarcopenia. Unraveling the underlying molecular mechanisms and developing effective treatments are crucial for improving the quality of life for those affected. In this context, accelerated aging models offer valuable insights into these conditions by displaying the hallmarks of human aging. Herein, this review focuses on relevant mouse models of musculoskeletal aging with particular emphasis on frailty, osteoporosis, and sarcopenia. Among the discussed models, PolgA mice in particular exhibit hallmarks of musculoskeletal aging, presenting early-onset frailty, as well as reduced bone and muscle mass that closely resemble human musculoskeletal aging. Ultimately, findings from these models hold promise for advancing interventions targeted at age-related musculoskeletal disorders, effectively addressing the challenges posed by musculoskeletal aging and associated conditions in humans. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000647854Publication status
publishedExternal links
Journal / series
Ageing Research ReviewsVolume
Pages / Article No.
Publisher
ElsevierSubject
Musculoskeletal aging; Accelerated aging mouse models; Frailty; Osteoporosis; Sarcopenia; PolgAOrganisational unit
03565 - Müller, Ralph / Müller, Ralph
More
Show all metadata
ETH Bibliography
yes
Altmetrics