Experimental study of microparticle transport in blood flow in a microfluidic bifurcation channel
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Date
2023-11-21Type
- Conference Paper
ETH Bibliography
yes
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Abstract
Transport of microparticles in the blood stream is of paramount significance for drug delivery. Blood flow in small vessels such as arterioles is known to display a segregation phenomenon called margination, where highly deformable red blood cells (RBCs) are preferentially found near the axial center of the vessel, segregating leukocytes and platelets in the near-wall region. This phenomenon is particularly important for the efficacy of targeted drug delivery in microcirculation (e.g. to tumor tissues), as the motion of drug-carriers and their distribution are strongly affected by their interactions with RBCs. We present an experimental study of the effects of hematocrit and particle concentration on RBC-particle interactions. We consider a microfluidic bifurcating channel of arteriole size, O(10) microns, in which 8-micron spheres flow along with RBCs, over a wide range of hematocrit and particle concentration. High-speed imaging and particle tracking velocimetry are leveraged to analyze the transport of RBCs and particles, up to whole-blood hematocrit levels. The results provide insights relevant to the underlying mechanisms of margination and the optimization of targeted drug delivery. Show more
Publication status
publishedExternal links
Journal / series
Bulletin of the American Physical SocietyPages / Article No.
Publisher
American Physical SocietyEvent
Subject
Fluid dynamics; Biomedical flowsOrganisational unit
09709 - Coletti, Filippo / Coletti, Filippo
Notes
Conference lecture on November 21, 2023More
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ETH Bibliography
yes
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