Nail disorders in a woman treated with Ixabepilone for metastatic breast cancer
Abstract
Ixabepilone (Ix) (BMS-247550®) is a potent member of a new class of microtubule-stabilizing cytotoxic agents known as epothilones. In pre-clinical studies, Ix has shown anticancer activity against several cancer types, including paclitaxel-resistant models, both in vitro and in vivo. The major toxicities associated with Ix are myelosuppression, sensory neuropathy and neutropenia. Other minor side-effects include asthenia/fatigue, stomatitis, anorexia, alopecia, skin reaction, hypersensitivity reactions and a fluid-retention syndrome. Although Ix is functionally correlated to taxanes, no previous evidence exists regarding Ix-related nail disorders. Here, we report a case of a 59-year-old woman treated with Ix at 40 mg/m2 day 1 q 21 days who, after 8 cycles of therapy, developed onycholysis and subungual hemorrhagic bullas in the fingernails. Show more
Publication status
publishedJournal / series
Anticancer researchVolume
Pages / Article No.
Publisher
International Institute of Anticancer ResearchSubject
Nail disorders; ixabepilone; breast cancerOrganisational unit
09703 - Alimonti, Andrea / Alimonti, Andrea
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