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Fabrication of Single and Multi-Layer Fibrous Biomaterial Scaffolds for Tissue Engineering
(2009)Proceedings of the ASME 2008 International Mechanical Engineering Congress and ExpositionFor regenerative medicine applications, we need to expand our understanding of the mechanisms by which nature assembles and functionalizes specialized complex tissues to form a complete organism. The first step towards this goal involves understanding the underlying complex mechanisms of highly organized behavior spanning not only diverse scientific fields, but also nano, micro and macro length-scales. For example, an engineered fibrous ...Conference Paper -
Design and Numerical Modeling of an On-Board Chemical Release Module for Motion Control of Bacteria-Propelled Swimming Micro-Robots
(2009)Proceedings of the ASME 2008 International Mechanical Engineering Congress and ExpositionOn/off motion control of bacteria-propelled synthetic bodies was previously achieved using a chemical switching technique. A chemical agent (CuSO4) directly binds to the rotor of the flagellar motor inhibiting it. When desired, a second chemical agent (EDTA) is introduced, which binds to the CuSO4 molecules, freeing the motor and allowing the bacteria to resume its motion [1]. To facilitate localized delivery of the control agents and ...Conference Paper -
Dry Spinning Polymeric Nano/microfiber Arrays using Glass Micropipettes with Controlled Porosities and Fiber Diameters
(2007)Proceedings of the 7th IEEE International Conference on NanotechnologyWe present a method for dry spinning polymeric nano/microfiber arrays. In this technique polymer solution is continuously ejected from a stationary glass micropipette and the fibers are deposited as continuous arrays in parallel and complex geometrical configurations on a rotating substrate mounted on to a translation stage. As the polymer solution exits the glass micropipette, ambient air is used to evaporate the solvent, thus solidifying ...Conference Paper -
Polymeric Micro/Nanofiber Manufacturing and Mechanical Characterization
(2009)ASME 2008 International Mechanical Engineering Congress and ExpositionPolymeric nanofibers are finding increasing number of applications and hold the potential to revolutionize diverse fields such as tissue engineering, smart textiles, sensors, and actuators. Aligning and producing long smooth, uniform and defect-free fibers with control on fiber dimensions at the submicron and nanoscale has been challenging due to fragility of polymeric materials. Besides fabrication, the other challenge lies in the ability ...Conference Paper -
Three-dimensional nanoscale manipulation and manufacturing using proximal probes: Controlled pulling of polymer micro/nanofibers
(2004)2004 IEEE International Conference on Robotics and AutomationBesides imaging and characterization, proximal probes are proposed to be use as a three-dimensional (3D) nanoscale manipulation and manufacturing tool In this work. We propose 3D nanoscale pulling of liquid polymer micro/nanofibers by precise positioning of atomic force microscope (AFM) nanoprobes and control of polymer solidification. An AFM probe is used to pull or extrude thermoset or thermoplastic polymers precisely to fabricate 3D ...Conference Paper