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Synthesis and biological activity of 12-aza-epothilones (azathilones) - non-natural natural products with potent anti proliferative activity
(2007)Chimia12-Aza-epothilones ('Azathilones') 1 and 2 have been prepared through ring-closing olefin metathesis or macrolactonization-based cyclization reactions. While RCM of the respective dienes 9 and 12 was found to be very effective and produced macrocyclic olefins with high E selectivity, the subsequent reduction of the 9,10-double bond proved to be unexpectedly difficult and low-yielding. Preparation of azathilone 2 was also accomplished via ...Conference Paper -
Nonlinear functional characterizations of uncertainty in model validation
(2002)IFAC Proceedings Volumes ~ Proceedings of the 15th IFAC World CongressModel validation provides a useful means of assessing the ability of a model to account for a specific experimental observation, and has application to modeling, identifi- cation and fault detection. In this paper we consider a new approach to the linear fractional transformation (LFT) model validation problem by deploying quadratic functionals, and more generally nonlinear functionals, to specify noise and dynamical perturbation sets. ...Conference Paper -
Asynchronous switching decentralized controllers for spacecraft formations
(2004)IFAC Proceedings Volumes ~ Automatic control in aerospace 2004The spacecraft formation control design problem is specified in terms of the relative positions of all spacecraft in the formation. Each spacecraft controller requires only a subset of the formation relative positions, and can switch asynchronously between many such information subsets, allowing it to replace measured information by information communicated from other spacecraft. A two dimensional simulation example is used to illustrate ...Conference Paper -
Alkali metal phenylphosphandlides, [M2PnPhn] (M = Li, Na)
(2005)ChimiaThe reaction of phenyldichlorophosphane, PhPCl2, a commercially important precursor for organophosphorus compounds, with lithium and sodium as reducing metals was re-investigated with the aim to well-characterize the resulting oligophosphandiides, [M2(PnPhn)(solv)x] (M = Li, Na). Experimental conditions for the optimal formation of these compounds were found for both series with M = Li and M = Na and several of these were crystallized and ...Conference Paper -
The influence of phase separation on the flow patterns of mid-ocean ridge hydrothermal systems
(2008)Geochimica et Cosmochimica ActaConference Paper -
More evidence of localization in the low-lying Dirac spectrum
(2005)PoS: Proceedings of ScienceConference Paper -
Parallel estimators and communication in spacecraft formations
(2005)IFAC Proceedings Volumes ~ Proceedings of the 16th IFAC World CongressThis paper investigates the closed-loop dynamics of systems controlled via parallel estimators. This structure arises in formation flying problems when each spacecraft bases its control action on an internal estimate of the complete formation state. For LTI systems a separation principle shows that the necessary and sufficient conditions for overall system stability are more stringent than the single controller case; the controllers’ ...Conference Paper -
How to Evaluate the Quality of Airborne Laser-Scanning Data
(2004)International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesThe discussion on the quality of digital elevation models form airborne laser scanner was dominated by the proof of vertical and horizontal accuracy. If the accuracy criteria were verified by ground control points, the evidence of high quality was produced. Based on experiences in projects for the Swiss Federal Office of Topography and according to the lidar requirements formulated by the US American ...Conference Paper -
Geometric validation of CARTOSAT -1 Imagery
(2008)International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesThe Institute of Geodesy and Photogrammetry (IGP) is participating in the Cartosat-1 evaluation program, a common initiative ofISRO (India) and ISPRS. Within this program, various test sites with reference data have been established and Cartosat-1 imageshave been acquired over these sites. We have reported already about the Rome and Mausanne datasets in a former publication. Here, we report about our ...Conference Paper -
Up to Date DSM Generation Using High Resolution Satellite Image Data
(2008)International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesDue to the increasing costs of high resolution satellite image data with stereo capabilities, products like accurate DSMs are becoming attractive for more and more users and applications. The Japanese optical sensor ALOS/PRISM which was launched in January 2006 has stereo capabilities by providing a simultaneous acquired image triplet. We have published several results of our evaluation of the potential of ALOS/PRISM image data together ...Conference Paper