Approaches for Trigger-Inducible Viral Transgene Regulation in Gene-Based Tissue Engineering
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Date
2004-10Type
- Journal Article
ETH Bibliography
yes
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Abstract
Recent advances in mammalian transgene expression dosing have resulted in a portfolio of mutually compatible systems that can adjust therapeutic transgene levels in response to antibiotics, hormone analogues, quorum-sensing messengers and secondary metabolites. The molecular merger of trigger-inducible expression technology with the latest generation of virus-derived transduction systems has enabled unmatched clinical interventions to shape desired therapeutic cell and tissue phenotypes for the treatment of complex human diseases. Show more
Publication status
publishedExternal links
Journal / series
Current Opinion in BiotechnologyVolume
Pages / Article No.
Publisher
ElsevierOrganisational unit
03663 - Aebersold, Rudolf (emeritus) / Aebersold, Rudolf (emeritus)
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ETH Bibliography
yes
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